ORAL CLONIDINE PREMEDICATION – ITS EFFECT ON INDUCTION DOSE OF THIOPENTONE SODIUM AND PERIOPERATIVE HEMODYNAMICS
Journal Title: PARIPEX-Indian Journal of Research - Year 2015, Vol 4, Issue 2
Abstract
Background: Proper premedication is important in general anaesthesia cases to reduce anxiety, to produce sedation analgesia, amnesia and to maintain hemodynamical stability during peri operative period. We studied the effect of oral clonidine premedication on the induction dose of intravenous thiopentone sodium and its effect on perioperative haemodynamics. Methods: Sixty ASA Grade 1 and Grade II patients were divided in to two groups,Group 1(study group) pre medicated with oral clonidine 4mcg/kg/body wt,Group II(control group) (no study drug administered). Dose of thiopentone sodium required and perioperative comparision of systolic blood pressure,diastolic blood pressure and heart rate in both groups assessed. Statistical analysis:the data was analysed using two tailed tests for differences between means of two samples(Z test) and in needed situation using x2 test.significant level for rejecting null hypothesis was taken p < 0.05. Results: The induction agent thiopentone sodium dose requirement is significantly reduced in group I(study group) clonidine pre medicaated patient compared to control group(Group II) (p value <0.0001). There was a very significant rise of systolic blood pressure,diastolic blood pressure and heart rate in control group(group II) compared to group I(study group). Conclusion: Pre medication with clonidine 4mcg/kg body weight ninety minutes before induction with thiopentone decreases the requirement of thiopentone and also attenuates the pressor response during gentle and smooth direct laryngoscopy and intubation.
Authors and Affiliations
Dr. J. Sudheer Kumar, Dr. Saya Raghavendra Prasad, Dr. M. Uma Maheswar
Keywords
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