Oral COX inhibitors for closure of hemodynamically significant Patent Ductus Arteriosus in Neonates : A retrospective analysis at a tertiary center in central India
Journal Title: Journal Of Pediatric Critical Care - Year 2017, Vol 4, Issue 3
Abstract
Background The efficacy of oral indomethacin/ ibuprofen in the closure of hemodynamically significant PDA is not extensively studied. Aim- Retrospective analysis of data on the efficacy and safety of oral cyclooxygenase (COX) inhibitors-indomethacin and ibuprofen in patent ductus arteriosus (PDA) closure. Materials and methods All preterm (28-36.6weeks) infants born between July 2011- June 2012 who received oral cyclooxygenase inhibitors for closure of PDA were included in the study. The outcome measured was closure rate of PDA. Results Of the 162 preterm neonates, 34 received oral COX inhibitors. Of them 27 received oral indomethacin and 7 received syrup ibuprofen. The total closure rate was 91.2% after first course and 8.8% of neonates required a second course with complete closure. No neonate required surgical closure. In the indomethacin group, 5 patients had thrombocytopenia and 1 had NEC. However, none of the cases in ibuprofen group had any significant side effects. Conclusion- Oral COX inhibitors are an effective therapy for closure of PDA.
Authors and Affiliations
Jenisha Jain, Gouri Rao Passi
Keywords
Related Articles
- EP ID EP336189
- DOI 10.21304/2017.0403.00203
- Views 74
- Downloads 0
Guidelines on Bronchiolitis Clinical AAP Guidelines summary: Bronchiolitis
.
Cardiorenal and Hepatorenal Syndrome
Cardiorenal syndrome(CRS) is an interdependent involvement of the heart and the kidney that leads to high morbidity, recurrent readmissions and grave prognosis. Early use of slow high-dose intravenous diuretics, dialysis...
Oxygenation Index at Onset vs at 24 Hours in PARDS
.
Effectiveness Of A Targeted Temperature Management Protocol Using A Cooling Blanket In Critically Ill Children With Acute Brain Injury
.
INSPIRED Multicenter data summary of Pediatric respiratory and cardiac ECMO from India
The use of ECMO in the recent times has been increasing in India signifi cantly. According to one source, there are more than 54 centres doing ECMO with more than 600 cases per year. Despite that information, reporting o...