ORAL DISINTEGRATING TABLETS(ODTS): A REVIEW
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2019, Vol 6, Issue 7
Abstract
Recently ODT terminology has been approved by United States Pharmacopoeia, British Pharmacopoeia, and Centre for Drug Evaluation and Research (CDER). US FDA defined ODT tablets as “A solid dosage form containing medicinal substances which disintegrates rapidly usually within a matter of seconds, when placed upon the tongue. The newest generation of ODTs can produce more robust, versatile tablets that overcome some of the limitations of earlier ODTs. The performance of ODTs depends on the manufacturing technology and the most necessary property of such a dosage form is the ability of rapidly disintegrating and dispersing or dissolving in the saliva, thereby obviating the need for water intake. Disintegrates are substances or mixture of substances added the drug to the formulation that facilitates the breakup or disintegration of tablets or capsule content into smaller particles that dissolve more rapidly than in the absence of disintegrates. Examples of superdisintegrants are croscarmellose, crosspovidone, sodium starch glycolate which represent example of cross linked cellulose.
Authors and Affiliations
Haritha Pasupulati
Keywords
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