Oral gabapentin for postoperative pain relief after lower limb surgery – a randomized controlled trail
Journal Title: Indian Journal of Clinical Anaesthesia - Year 2017, Vol 4, Issue 1
Abstract
Introduction: In addition to anticonvulsant property of gabapentin, it was demonstrated that gabapentin also possesses analgesic property. In this randomized control trial the efficacy of gabapentin for postoperative pain relief was studied on 60 adult patients of either sex, belonging to ASA grade I or II, in the age range of 18-60 years posted for lower limb surgeries under spinal analgesia. Methods: The patients were randomly divided into two groups of 30 patients each. Group A patients (n=30) received oral gabapentin 1200 mg 2 hours prior to scheduled surgery and the same dose was given at 9:00 am on the first and second postoperative days. Group B (n=30) served as control group received only placebo capsules. Subarachnoid block was established in both the groups by administering 4 ml of hyperbaric bupivacaine. Vital parameters such as heart rate, blood pressure respiratory rate along with pain assessment (VAS) were recorded at regular intervals in the postoperative period. Rescue analgesia was provided with intramuscular butorphanol. Results: It was observed that patients in group A exhibited excellent quality of postoperative pain relief as compared to group B (P<0.0001). The requirement of opioids in the form of butorphanol was greatly reduced in group A as compared to group B (P<0.0001). Patient satisfaction using verbal rating scale was higher in Group A as compared to group B (P<0.0001). Minor side effects encountered were mild sedation, shivering, nausea, vomiting and dizziness which showed no significant difference between the groups. Conclusion: Oral administration of gabapentin holds great promise for excellent postoperative pain relief and reduction in the overall requirement of opioids without producing significant side effects.
Authors and Affiliations
Thasleem Arif K, Binil Isaac Mathew, Vijish Venugopal
Keywords
Related Articles
- EP ID EP311245
- DOI 10.18231/2394-4994.2017.0009
- Views 129
- Downloads 0
A study to evaluate the effectiveness of Bupivacaine (0.5%) versus Ropivacaine (0.5%, 0.75%) in patients undergoing upper limb surgery under brachial plexus block
Introduction: Brachial plexus block is the commonest form of regional anaesthesia being used for upper limb surgeries. Bupivacaine is most widely used local anaesthetic in regional anaesthesia, but its cardiotoxicity has...
Anesthetic considerations in an infant with congenital cystic adenomatoid malformation
Congenital cystic adenomatoid malformation (CCAM) is a rare developmental disorder of lower respiratory tract in which child presents with severe respiratory distress, pneumonitis or sepsis. Anesthetic management of such...
Comparison of the effect of oral esomeprazole with pantoprazole on gastric pH and gastric volume: “A randomised double blind placebo controlled study”
Aim: This study aims to evaluate the effects of prophylactic use of oral esomeprazole, pantoprazole and Placebo on Gastric pH and Gastric volume at the time of induction (post-induction) and at recovery (pre-extubation),...
Comparison of channelled vs unchannelled video laryngoscope- A prospective randomised trial
Introduction Conventional laryngoscopy using the traditional Macintosh blade remains the commonest method of tracheal intubation in the routine clinical scenario Video laryngoscopes have taken over this position in many...
A comparative study of efficacy and safety of oral ketamine and oral midazolam as premedicant for paediatric cardiac catheterization
Use of an effective sedative premedicant significantly minimizes the emotional trauma associated with perioperative anxiety and its sequelae Currently oral midazolam is the most commonly used premedicant in most of the c...