Orthopedic Models and Imaging Techniques in Preclinical Researchs
Journal Title: Nükleer Tıp Seminerleri - Year 2019, Vol 5, Issue 1
Abstract
Tendinopathies and osteoarthritis developed after cartilage damage are chronic health problems that decrease the patient’s quality of life. Osteoporosis is another important health problem leading to fractures. In the treatment of osteoporotic fractures, satisfactory results cannot be achieved. In recent years, studies intended to understand the mechanisms underlying the fracture healing, and also, to provide the regeneration of cartilage and tendon have increased. Animal models are used to improve understanding of complex processes and related mechanisms in fracture healing. In cartilage and tendon pathologies, it is inevitable to use animal models in order to investigate new surgical methods and to develop and test surgical implants and materials. While tissue engineering models aim to produce new cells that will provide regeneration, orthopedic surgery models focus on implant and biomechanical research. In planning pre-clinical orthopedic studies, appropriate methods should be chosen in order to evaluate the results correctly. Histological methods are important in evaluating the microstructural properties of tissues. In addition, quantitative assessments obtained by imaging modalities provide valuable information for adaptation of the results to the clinic.
Authors and Affiliations
Deniz Bedel, Fatma Suna Kıraç
Keywords
Related Articles
- EP ID EP549627
- DOI 10.4274/nts.galenos.2019.0010
- Views 88
- Downloads 0
Pathological Examination of Sentinel Lymph Node Biopsy
Sentinel lymph node biopsy SLNB is a standardized method with a high accuracy rate, which is currently applied in many centers at the stage of axillary lymph node involvement of early stage, clinically node-negative brea...
Role of Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Imaging in Diagnosis and Staging of Lung Cancer
Positron emission tomography/computed tomography (PET/CT) using fluorine-18 labelled fluorodeoxyglucose (FDG) is a powerful tool for managing patients with suspected lung nodules and lung cancer. In this review, we discu...
Preclinical Models and Imaging Techniques for Studing Prostate and Colorectal Cancers
DUAs with all cancer types, the initiation, development, and metastatic stages of prostate and colorectal cancers, are very important to understand the relationship between tumor cells and normal cells in the stroma, the...
Lu-177 Prostate Specific Membrane Antigen Therapy of Metastatic Castration Resistant Prostate Cancer
Lu-177 prostate-specific membrane antigen (PSMA) has been increasingly used for treatment of metastatic castration-resistant prostate cancer. It is effective in pain palliation for bone metastasis and improves patient pe...
Natural and Artificial Radiation Sources and Personal Dose Additives
Radiation is defined as the energy in motion. Since the creation of the universe, all living creatures and humans are exposed to radiation in more or less levels. There is radioactivity naturally in the air, in the foods...