OSTEOMALACIA REVEALING A SYNOVIAL SARCOMA OF THE NASAL CAVITY
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2019, Vol 6, Issue 1
Abstract
Oncogenic osteomalacia is an acquired, rare paraneoplastic syndrome characterized by renal phosphate wasting and subsequent hypophosphatemic osteomalacia. We report a case of oncogenic osteomalacia associated with a phosphaturic mesenchymal tumor in a 41-year-old woman. She presented with pelvicrural pain. There was also a lateral-left nasal swelling 3 cm in diameter with no other symptoms. BMD revealed a remarkable decrease in lumbar spine BMD (Tscore to - 5.2 DS). Radiologic examination showed multiple pathologic fractures of the pelvis. Severe hypophosphatemia, hyperphosphaturia, low plasma 1,25-dihydroxyvitamin D3 level were disclosed at presentation. Computed tomography of the facial bones showed a large tumor formation of the left nasal cavity in connection with a synovial sarcoma (SyS) confirmed by immunohistochemistry. After removal of the tumor, - biochemical and hormonal abnormalities disappeared with remarkable symptomatic improvement. In conclusion, although an extremely rare disease, clinicians and pathologists should be aware of the existence of Tumor induced osteomalacia.
Authors and Affiliations
D. Kaffel
Keywords
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