Osteotropism of Breast and Prostate Cancer: Clinical and Experimental Perspective
Journal Title: International Journal of Immunotherapy and Cancer Research - Year 2017, Vol 3, Issue 2
Abstract
Breast and prostate cancer are the two most common invasive cancers in women and men, respectively. Although these cancers arise in organs that are different in terms of structure and function, both organs require sexual hormones for their development, and tumors that arise from them are typically hormone-dependent and have extraordinary affinity each other [1]. That breast and prostate cancer share several biological, genetic and epidemiological aspects is known since 1950s. Pioneering studies designed to ascertain the genetic bases of breast cancer detected a higher frequency of prostate cancer among the relatives of women with breast cancer, which led them to propose that prostate cancer could be the male equivalent of at least some female mammary carcinomas [2].
Authors and Affiliations
Scimeca Manuel, Starace Francesca, Gratti Deborah, Sapia Viviana Benedicta, Bonfiglio Rita, Bonanno Elena
Anti-VEGF Therapy Induces Proteinuria through Endothelial Disorganization Leading to Nephrin Decrease in Podocytes
Background: VEGF is involved in cancer development by stimulating neo-angiogenesis and tumor proliferation. Anti-angiogenic therapies, especially tyrosine kinase inhibitors such as sunitinib, have significantly improved...
Regulation of Protein Degradation and Homeostasis by the Cytokine- Inducible Deubiquitinating Enzymes
Ubiquitin-proteasome system (UPS) is the major signaling pathway responsible for regulating protein turnover in cells. Deubiquitinating enzymes (DUBs) have an important role in this signaling pathway by eliminating ubiqu...
A Very Rare Case of Polycythemia Vera Patient Who Developed Other Four Cancers
We find more and more often patients with two or more synchronous or metachronous cancers, who raise various issues on the risk factors and pathways. A polycythemia vera male patient, diagnosed at 44 years, evolved towar...
Analysis of Risk Factors for Development of Hepatocellular Carcinoma in Chronic HBV - Infected Liver Cirrhosis Patients: A Meta-Analysis
The 5-year cumulative incidence rate of hepatocellular carcinoma (HCC) in chronic HBV -infected liver cirrhosis (LC) patients was up to 5%-30%. However, existing medical interventions can’t cure chronic HBV -infected LC...
A Study of Glucosylceramide Synthase and Glycolytic Pathway Enzymes in Patients with Hypereosinophilia
Glucosylceramide synthase is the rate limiting enzyme in ceramide glycosylation and shifts the balance between ceramide and glycosphingolipids towards proliferation and survival of cancer cells. Increased glucose availab...