Our experience with CEA in the management of colorectal cancer – a prospective study
Journal Title: Asian Pacific Journal of Health Sciences - Year 2017, Vol 4, Issue 2
Abstract
Introduction : In India, colorectal cancer is the 6th most prevalent cancer and population based time trend studies show a rising trend in its incidence. CEA is expressed in significant amounts post-natally by the carcinomas arising from large intestine. Currently, the most useful application of CEA is in the detection of liver metastasis from colorectal cancers and serial determination of CEA is recommended for detecting cancer spread to the liver. Aim: To assess the role of CEA in the management of colorectal cancer, and detection of early recurrence. Methods and Material: 30 patients with colorectal cancer admitted in Vydehi Institute of Medical Sciences & Research Centre during the period of November 2012 to April 2014 were included in a prospective study. Statistical analysis used: Descriptive statistics were calculated for all variables. Analysis was performed using the SPSS 14.0 statistical package. Results: Total patients included in the study was 30. The mean age at presentation was 48.66yrs. The most common site of malignancy was rectum (46.66%), and most of the patients presented in stage I. Pre-operatively CEA was raised in 22 cases. On postoperative follow-up, CEA was found to be elevated in 7 cases. 6 out of these cases had proven recurrence. One case was found to have peritoneal deposit in spite of CEA levels being normal. The sensitivity and specificity of using CEA as an indicator for recurrence were 85.71% and 95.65% respectively. Conclusions: Since colorectal cancer is associated with considerable morbidity and mortality, early diagnosis and management provide a chance for better survival. The use of CEA as an early indicator for recurrence has been evaluated in this study and can be used for the same. However, a larger size and longer duration of study is needed to effectively prove the same.
Authors and Affiliations
Dr. Shweta Mallick
Keywords
Related Articles
- EP ID EP525743
- DOI 10.21276/apjhs.2017.4.2.11
- Views 167
- Downloads 0
Paravertebral block versus unilateral spinal anesthesia for inguinal hernia repair - A comparative clinical trial
Background: Inguinal hernia repair can be performed under satisfactory anesthetic conditions using general, regional, and peripheral nerve block anesthesia. Aims and Objectives: The aim of this study is to evaluate wheth...
Salivary gland neoplasms: Histomorphological assessment of an enigmatic group of tumours
Introduction: Salivary gland tumours are complex and exhibit varied clinico-pathological features.These tumours are particularly important to the otolaryngologists, head and neck surgeons and oncologists because of their...
Effect of dexmedetomidine on propofol requirement during elective spine surgery in adolescents
Background: Total intravenous anesthesia with propofol and a synthetic opioid is a frequently chosen anesthetic technique for posterior spinal fusion. Aims and Objectives: The aim of this study is to evaluate the effect...
Cytodiagnosis of Ewings sarcoma, hip and its confirmation on immunohistochemistry: A case report
Ewings sarcoma is an important childhood malignancy. The patient usually presents in an advanced stage and before definitive or palliative therapy can be instituted, rapid and precise diagnosis is imperative. Fine needle...
Prevalence and risk factors associated with Syphilis at the Copperbelt University Riverside campus, Kitwe Zambia
Background: Syphilis among other sexually transmitted diseases is a major health concern among college and university students. Studies have proven that university students in Africa comprise of sexually active populatio...