OUTCOME OF TOCILIZUMAB THERAPY IN CHILDREN WITH SYSTEMIC-ONSET JUVENILE IDIOPATHIC ARTHRITIS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 23
Abstract
BACKGROUND Globally, 3 lakh children suffer with idiopathic arthritis amongst which systemic is about 10% to 25%. The morbidity of arthritis is severe, mortality is about 2% - 4% and hence different treatment protocols are used. Aims and Objectives- To find out the clinical and laboratory outcome of Tocilizumab in children with SOJIA. MATERIALS AND METHODS It is a descriptive study. Methods- 24 children of above 3 years to sixteen, who satisfied ILAR criteria for systemic onset, who were already on DMARDs and attended the rheumatic care centre at Rajiv Gandhi Govt. General Hospital were included between March 2014 and March 2017. Other types of JIA and very sick children were excluded. Tocilizumab 8 mg/kg was given every month and the clinical and laboratory assessment, ACR disease activity core set index were done at baseline and at 6 months. RESULTS Amongst 24 children, there were 3 dropouts. Tocilizumab was given in 12 doses in 6, 6 doses in 7, 7 doses in 4 and 3 doses in 4. Male: Female seen as 16: 5 or 3.2: 1. Mean age in the cohort was 9.1 ± 0.729. Mean disease duration was 4.09 ± 0.43. Investigation showed Mean ESR 69.05 ± 3.78 and 38.09 ± 2.52; Mean CRP 25.71 ± 4.06 and 5.43 ± 1.30; Mean WBC 18.92 ± 2.66 and 9.54 ± 0.56; Mean platelet 6.27 ± 3.7 and 4.68 ± 0.189 before and after Tocilizumab therapy. CONCLUSION Tocilizumab therapy for systemic JIA reduces systemic activity to large extent along with articular inflammation, seen as drop in CRP and ESR and platelet with improvement in ACR 30% in this study.
Authors and Affiliations
Balameena S. , Ravichandran R.
Keywords
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- EP ID EP439323
- DOI 10.14260/jemds/2018/620
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