Overweight and obesity as important risk factors for cytostatic-induced liver injury in patients with acute leukemia
Journal Title: Український терапевтичний журнал - Year 2018, Vol 0, Issue 2
Abstract
Objective — to determine the role of overweight and obesity in the hepatotoxic reactions development in patients with acute leukemia (AL). Materials and methods. The examinations involved 58 patients with newly diagnosed AL. Patient’s age was 22—63 years, the ratio of women and men was 26 (44.8 %)/32 (55.2 %), respectively. The patients were divided in groups according to the results of body weight index: I (n = 30) — patients with normal weight; ІІ (n = 28) — patients with obesity and overweight. Patients were examined three times: at baseline before starting chemotherapy (CT), on the 28th and 56th days. The activity of alanine (ALT) and aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGTP), alkaline phosphatase (ALP), total bilirubin (TB) in the blood serum were determined. The hepatotoxic reactions’ severity was performed according to the criteria of the National Cancer Institute (NCI). Results and discussion. On the 56th day of treatment in patients of group I with normal weight, the following trends were determined: tendency to increase of ALT activity in the blood serum in 1.8 times, AST — in 1.3 times, ALP — in 1.6 times, GGTP — 1.9 times in comparison with the baseline levels (p > 0.05). The preservation of serum TB level within the normal values was noticed. In patients of group II with overweight and obesity there was a significant increase in ALT activity in 2.6 times, AST — in 2.5 times, GGTP — in 2.6 times, APL — in 3.7 times, as well as TB serum level increase in 3.6 times compared with the baseline. In addition, hepatotoxic reactions were observed in 7 (23,3 %) patients in group І and in 19 (67.8 %) patients in group ІІ. In patients of group I hepatotoxicity did not exceed grade I, and in group ІІ — in 8 (28.6 %) patients hepatotoxicity was of grade I and in 11 (39.3 %) patients — grade II. Conclusions. Overweight and obesity were proved as essential risk factors for the development of hepatotoxic reactions in the CT pattern of acute leukemia.
Authors and Affiliations
I. M. Skrypnyk, G. S. Maslova
Keywords
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- EP ID EP420739
- DOI 10.30978/UTJ2018-2-21
- Views 117
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