Oxidative Stress (MDA) Levels and Urinary Protein-Creatinine Ratio in Pre-Eclamptic Patients Attending in the Outpatient’s Clinic in A Tertiary Care Hospital
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 4
Abstract
Objective: To evaluate the serum levels of malondialdehyde as marker of lipid peroxidation and to estimate urinary protein-creatinine ratio to evaluate proteinuria. Methods: This was a case-control study. The study was approved by the ethical committee of the institute. The consent was taken from each patient before enrolling in the study. The cases comprised of pre-eclampsia patients. The control group consisted of age matched normal pregnant women. Both cases and control were interviewed to obtain the relevant data after taking informed consent. Based on inclusion and exclusion criteria, 30 cases were selected and 30 age matched normal pregnant women were taken as controls. Results: There was no significant (p>0.05) difference in age, height, weight and BMI between cases and controls. The lipid peroxidation product, MDA was significantly increased in the cases as compared to the controls (p=0.001). There was significant difference in the Protein-creatinine ratio between cases and controls. There was significant (p=0.001) difference in the Protein-creatinine ratio between nonsevere and severe Pre-eclampsia. Conclusion: The protein-creatinine ratio was found to be significant predictor of proteinuria with a reasonable sensitivity and specificity.
Authors and Affiliations
Dr. Prabhakar Singh Bais
Keywords
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