Pain on Propofol Injection: Comparative Study of Pre-Treatment with Intravenous Lignocaine, Ondansetron and Fentanyl for the Prevention of Pain
Journal Title: Indian Journal of Anesthesia and Analgesia - Year 2019, Vol 6, Issue 4
Abstract
Context: Propofol is a sedative-hypnotic intravenous anaesthetic agent. It causes a high incidence of pain during intravenous injection which leads to patient dissatisfaction. Aim: The aim of this study was to determine whether pre-treatment with intravenous lignocaine, ondensetron and fentanyl was effective in reducing propofol induced pain. Settings and Design: In a prospective, randomized, double blind study 150 ASA physical status I and II patients, aged 20-60 years, undergoing elective surgery under general anesthesia, were allocated randomly into three groups. Methods and Material: Group A received IV lignocaine 42 mg (2 ml), Group B received IV ondansetron 4mg and Group C received IV fentanyl 100 mcg. Mid-arm was occluded before drug injection then released after 1 min followed by propofol injection. Patients were assessed according to Mc Crirrick and Hunter pain scoring system at 0, 5, 10, 15 and 20 seconds. Statistical analysis: ANOVA with Dunnett’s post hoc test and chi-square test were used to analyze results. Results: Two patients in Group A and one patient in Group B had ‘no pain’ during the observation period. Group B and Group C have more ‘mild pain’ than Group A while it is comparable in Group B and C. ‘Moderate pain’ is comparable between Group A and B while Group A has more ‘moderate pain’ than Group C and Group B has more ‘moderate pain’ than Group C. Only one patient in Group A had ‘severe pain’. Conclusion: Pre-treatment with lignocaine, ondensetron and fentanyl was effective in reducing pain on propofol injection but the superiority of one drug over the other cannot be commented.
Authors and Affiliations
Chetan Arun Patil
Keywords
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- EP ID EP668023
- DOI 10.21088/ijaa.2349.8471.6419.38
- Views 89
- Downloads 0
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