Palliative Radiotherapy for Bone Metastases – A Prospective Study Comparing Different Fractionation Schedules
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 4
Abstract
Bone metastasis is a common manifestation of malignancy, causing various morbidities. The mainstay of treatment of uncomplicated painful bone metastases is palliative radiotherapy. The purpose of this study is to assess and compare the efficacy of different radiotherapy fractionation schedules in terms of pain relief. 80 patients were randomised to 4 different radiotherapy fractionation schedules of8Gy in 1 fraction, 20 Gy in 5 fractions, 24 Gy in 6 fractions and 30 Gy in 10 fractions. Pain was assessed by Visual Analog Scale (VAS), performance status and analgesic usage. Significant pain reduction was seen in all the arms. Mean VAS score prior to radiotherapy was 5.23, and this reduced to 2.88 on treatment completion.Post radiotherapy, the scores reduced to 0.79 and 0.81, at 1 month and 3 months respectively. Complete pain relief was seen in 40% of the patients. 25% of the patients in 8 Gy in 1 fraction had complete pain relief, whereas in the remaining 3 arms this was 45% each. It was concluded that the different fractionation schedules of radiotherapy used in the treatment of painful bone metastases have been found to be effective in reducing pain, with no significant difference seen between the groups.
Authors and Affiliations
Muhsina V, Hasib AG, Athiyamaan MS, Sandesh RB, Sharaschandra S, Shreyas R
Keywords
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