Pancreatic cancer: From Molecular Biology to Management
Journal Title: Pakistan Journal of Pharmaceutical Research - Year 2016, Vol 2, Issue 2
Abstract
Pancreatic cancer is a lethal disease due to which its early prognosis is necessary. Pancreatic cancer causes the death of many patients. We have to take some preventive measures for our safety. As to quit smoking which is the main cause of PaC. The treatments which are available as surgery, chemotherapy, radiotherapy are not that successful. Due to which we have to know about the genomics of PaC. Which genes are involved in cancer. Genes which altered during PaC are DPC4, p53, and p16 and CDKN2 (Cyclin-Dependent Kinase Inhibitor 2A). though the understanding about those genes we can trace out the actual problem and that problem can be cured. We can treat this disease if we have knowledge about biomarkers which act as a drug target to treat the disease. The available biomarkers now days are miRNAs, CA 19-9 and carcinoembryonic antigen (CEA) which give the early prognosis of cancer possible. Several drug target are discovered that will help out in disease treatment. If we inhibit these inhibitor farnesyltransferase, EGFR tyrosine kinases (epidermal growth factor receptor) ,ERK1/2 (Extracellular Signal-Regulated Kinase) the growth of tumor can be reduced.
Authors and Affiliations
Muhammad Imran Qadir
Keywords
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