Parallel Mechanisms between Placental Amyloidosis/Preeclampsia and Neurodegenerative Diseases
Journal Title: Asian Journal of Biology - Year 2017, Vol 2, Issue 4
Abstract
This short review summarizes recent studies on placenta-preeclampsia in the mother and/or intrauterine growth restriction in the child. The ideas raised here are framed within a paradigm that favors the opening of new research lines in these themes and are focused on the outlining of early investigation and/or an adequate treatment for mothers who develop the pathology. Thus, this review focuses on those studies that categorize PE in the group of pathologies defined as "conformational diseases", as a consequence of the misfolding of proteins due to endoplasmic reticulum ER stress. In this particular case, the ER stress that develops in the syncytiotrophoblast because of the oxidative stress caused in the placenta by the hypoxia that occurs as a consequence of the failure in the remodeling of endometrial arteries. This leads to an increased syncytiotrophoblast apoptosis with detachment of misfolded proteins into the maternal circulation, which in turn would be primarily responsible for the signs of preeclampsia in the mother: proteinuria, edema, and hypertension. The review also analyzes the preeclampsia-prions-placenta relationship, since the normal cell-surface protein PrPc is normally present in the plasma membrane of syncytiotrophoblast, but appears to be increased in cases of preeclampsia. However, although neurodegenerative disorders resulting from conformational changes in the prion protein from its normal cellular form, PrPc, to the infectious scrapie isoform, PrPSc are well known, limited information is available on Pr Pc and PrPSc in the ST, hence review on these proteins gains more attention in normal and pathological placenta.
Authors and Affiliations
C. Bosco, E. Díaz
Keywords
Related Articles
- EP ID EP337821
- DOI 10.9734/AJOB/2017/33756
- Views 96
- Downloads 0
Comparative Evaluation of the Effect of Annona muricata (Graviola) Leaves Extracts and Cefoxitin on Staphylococcus aureus
Resistance of Staphylococcus aureus to beta- lactam drugs most especially cefoxitin is a known global problem. Current researches are geared toward evaluating the antimicrobial properties of medicinal plants against thes...
Some New Information on Ants’ Cemeteries Organization
Aim: We aimed to explain how ants manage to deposit nestmate corpses outside their nest. Methodology: We first summarized a previous study of ours dealing with the subject, and reported others carried out in the meantime...
Prevalence of Parasites Infection of Resident Fish Species in a Tropical Reservoir
This study detected, identified and determined the incidence of parasites present in and on Clarias gariepinus, Sarotherodon galilaeus, Oreochromis niloticus and Tilapia zillii in Ero reservoir, a tropical reservoir situ...
Evaluation of Botanicals Toxicants against Root-knot Nematode, Meloidogyne incognita in vitro
The present experiment was carried out to investigate the nematostatic and nematicidal potential of aqueous extracts of six weed leaves viz., Ageratum conyzoides, Eichornia crassipes, Ipomoea carnea, Nicotiana plumbagini...
Effect of Obesity on Selected Reproductive Parameters in Female Sprague Dawley Rat (Rattus norvegicus) Model
Aims: To determine changes in frequency of occurrence and durations of estrous cycle stages and measure serum levels of cortisol and estradiol in Sprague Dawley rats. Study Design: Laboratory Experimental research Desig...