PARAMETERS AND MORPHOLOGICAL CHANGES OF ERYTHROCYTES IN COVID-19 SUBJECTS
Journal Title: International scientific journal Science and Innovation - Year 2023, Vol 2, Issue 8
Abstract
Objective: to assess the morphological abnormalities of red blood cells (RBC) in patients with COVID-19 and cardiovascular system (CVS) pathology. Material and methods. The study included 142 patients who were divided into 3 groups according to the following principle: combination of COVID-19 and CVS pathology (group 1, n=56); COVID-19 without CVS pathology (group 2, n=44); patients with CVS pathology without COVID-19 (group 3, n=42). Peripheral blood erythrocytes were studied. Morphological studies were carried out in the laboratories of pathological anatomy of the State Institution âRSSPMC for surgery named after V.Vakhidov" and RSH Zangiota-1. Results. Morphological features of peripheral blood erythrocytes in COVID-19-associated cardiovascular syndrome were revealed, characterized by an increase in the frequency of elevated erythrocyte distribution width (RDW) from 45.5% to 67.9% (p<0.05), and the average RDW from 13.1% (11, 8-15.4%) to 14.3% (12.6-15.8%) (p<0.0001); an increase in the proportion of abnormal forms from 13.6% in the isolated course of COVID-19 to 32.1% in the combination of COVID-19 with cardiovascular pathology (p<0.05), mainly due to ridged erythrocytes from 6.4+0.5% to 8.2+0.6% (p<0.001) and the proportion of irreversible forms of erythrocytes from 1.6+0.1% to 3.1+0.3% (p<0.001) increasing the risk of transferring the patient to the ICU (RR=6.0) and death (RR=4.33). Patients with more than 20% RBC abnormality had a statistically significant higher ICU admission rate (50.0%, 9 of 18; RR=6.0) than patients with less than 10% RBC abnormality (8.33%, 1 of 12, p=0.049), and patients with 10-20% abnormal RBCs (7.7%, 2 of 26, p=0.005). Conclusion. Patients with COVID-19-associated cardiovascular syndrome have a significant morphological heterogeneity in the shape and size of erythrocytes and their relationship with the progression and outcome of the disease.
Authors and Affiliations
Ibadov Raufbek Ravshanovich, Akilov Khabibulla Ataullayevich, Mardonov Jamshid Normurotovich
Keywords
Related Articles
- EP ID EP721104
- DOI 10.5281/zenodo.8219267
- Views 46
- Downloads 0
EFFECT OF A TRIAZOLE DERIVATIVE ON MITOCHONDRIAL LIVER DYSFUNCTION IN ALLOXAN DIABETES
In recent years, the use of herbal preparations in the treatment of diseases has been growing significantly, which is explained by their therapeutic effectiveness and low negative effects on the body. Medicinal substance...
STUDY OF THE PROCESS OF PURIFICATION OF ZINC SULFATE SOLUTIONS FROM IMPURITIES
The article describes the procedure for removing different contaminants via sulfate of zinc solution, including iron, copper, and cadmium ions in detail. Studies have been conducted on the use of zinc dust in the applica...
AXIOLOGICAL AND ACMEOLOGICAL ASPECTS OF PREPARING STUDENTS FOR TECHNOLOGY AND TECHNIQUES OF EFFECTIVE COMMUNICATION
In the conditions of the 21st century, a new ideal of an educated person in the world is being created, who must have not only physical, but also mental, spiritual, moral, aesthetic, ethical, informational, communicative...
DEVELOPMENT OF WOMEN'S EDUCATION: HISTORY, PROBLEMS AND PROSPECTS
In the development of women's education, it is important to pay attention to its history, problems and prospects. This issue served to enrich the content of this article
THE USE OF NEGATIVE POLITENESS STRATEGIES IN A WORK OF ART (BASED ON THE ANALYSIS OF THE WORKS OF TAHIR MALIK)
The article shows that there are four basic politeness strategies that can be summarized based on Brown and Levinson's theory, when and where to use one of these politeness strategies, negative politeness, based on the w...