PARKINSON’S DISEASE: A PHYTOCHEMICAL APPROACH
Journal Title: Int J of Pharm Rev& Res - Year 2014, Vol 4, Issue 2
Abstract
Parkinson’s disease (PD) is a progressive and age-dependent neurodegenerative movement disorder. It is characterized by a selective loss of dopaminergic neurons in the substantia nigra pars compacta (SNPC) region of the midbrain that culminates in the major clinical symptoms of PD. The etiology of the neuronal cell death is still unclear, but mitochondrial dysfunction, oxidative stress and subsequent apoptotic cell death have been considered as underlying mechanisms of dopaminergic cell death. Although the current therapeutics applied for this disorder produce a symptomatic relief, treatment strategies for slowing down the disease progression are yet to be developed. Under these circumstances with no causal therapy is yet available, biomedical researchers are turning their interests towards exploiting the wealth of traditional knowledge on medicinal plants. This review presents the current scientific information on the neuroprotective potential of traditional plants like Mucuna pruriens, Gingko biloba, Panax ginseng, Centella asiatica, Bacopa monnieri, Withania somnifera, Scutellaria baicalensis and some popular phytochemical constituents. This information may contribute largely for developing better protective neurotherapeutics for Parkinson’s disease in near future.
Authors and Affiliations
S. Divya1 , S. Kavimani1 , S. Sudha Rani2 , S. Subashree , Syam Praveen Kumar2 , G. Mahalakshmi , T. Nirmala1 , R. Samundeswari1 , D. Sivassoupramanian1
Keywords
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