Partial genome analysis of cox1 subunit-I region in mitochondrial dna of canine mammary tumours
Journal Title: Journal of Veterinary and Animal Sciences - Year 2021, Vol 52, Issue 1
Abstract
Oncogenesis is an area which continuously elicits research interest. There are innumerable factors which contribute to oncogenesis of which mitochondrial DNA (mtDNA) mutations play a major role. Though extensive studies have been conducted relating mtDNA mutations to human cancers, there is sparse information available on canine neoplasia. Cytochrome oxidase1 (COX1) is an important component of electron transport chain of mitochondria and any alteration in it would result in altered energy production which is very essential for proliferating neoplastic cells. Two samples of canine mammary carcinomas (CMT) were subjected to partial genome sequencing of COX1 subunit -I. There was no change in the gene sequence of COX1. Further studies in this aspect would pave the way for investigations on the role of mtDNA mutation in oncogenesis and could provide insights into how canines can serve as models for human cancers.
Authors and Affiliations
K. Krithiga Arathi Rajan Geetu Rose Varghese R. L. Neetha Dipyaman Patra Neethu Krishnan Arathy Warrier Priya Srinivas
Keywords
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- EP ID EP699415
- DOI 10.51966/jvas.2021.52.1.95-98
- Views 82
- Downloads 0
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