Partial genome analysis of cox1 subunit-I region in mitochondrial dna of canine mammary tumours
Journal Title: Journal of Veterinary and Animal Sciences - Year 2021, Vol 52, Issue 1
Abstract
Oncogenesis is an area which continuously elicits research interest. There are innumerable factors which contribute to oncogenesis of which mitochondrial DNA (mtDNA) mutations play a major role. Though extensive studies have been conducted relating mtDNA mutations to human cancers, there is sparse information available on canine neoplasia. Cytochrome oxidase1 (COX1) is an important component of electron transport chain of mitochondria and any alteration in it would result in altered energy production which is very essential for proliferating neoplastic cells. Two samples of canine mammary carcinomas (CMT) were subjected to partial genome sequencing of COX1 subunit -I. There was no change in the gene sequence of COX1. Further studies in this aspect would pave the way for investigations on the role of mtDNA mutation in oncogenesis and could provide insights into how canines can serve as models for human cancers.
Authors and Affiliations
K. Krithiga Arathi Rajan Geetu Rose Varghese R. L. Neetha Dipyaman Patra Neethu Krishnan Arathy Warrier Priya Srinivas
Keywords
Related Articles
- EP ID EP699415
- DOI 10.51966/jvas.2021.52.1.95-98
- Views 83
- Downloads 0
Association of temperature humidity index during summer with haematological parameters in native and crossbred goats of Kerala
The study was conducted to investigate the association of temperature humidity index (THI) during summer with haematological responses in Malabari, crossbred and Attappady goats of Kerala. The research work was conducte...
Minor salivary glands in oral mucosa of two dogs: A pilot study
Presence of minor salivary glands in the oral mucosa and its potential use as an autograft for treating dry eye disease has been widely reported in humans. But there is a paucity of literature regarding the histological...
Effect of dietary energy and lysine levels on cost of production and profit of meat production in “TANUVAS Namakkal gold Japanese quails”
Two biological trials were conducted to determine the energy and lysine requirements of “TANUVAS Namakkal gold Japanese quail” for production performance. The economic impact of different levels energy and lysine durin...
Annual temperature profile of Thrissur: a climate change perspective
Climate change is one of the most serious issues faced by the global community of the present era. Hence, maximum, minimum and average temperatures for the period 1986 to 2016 collected from the Department of Agricultur...
Multi-locus sequence typing for species/ serovar identification of clinical isolates of Leptospira spp.
Leptospirosis is an emerging zoonotic disease endemic in Kerala and close monitoring of emerging serovars is essential to adopt appropriate control strategies. Multi-Locus Sequence Typing (MLST) was reported to be less...