Pathogenesis of Cerebrovascular Malformations and Anti-Ki-67 (MIB-1) Proliferating Index

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Pathogenesis of Cerebrovascular Malformations and Anti-Ki-67 (MIB-1) Proliferating Index

Journal Title: Journal of Neurological Sciences-Turkish - Year 2005, Vol 22, Issue 3

Abstract

The pathogenesis of cerebrovascular malformations is currently unknown. Lately recent researchs suggest that their pathogenesis and development might be due to a series of factors taking part in angiogenesis. Angiogenic growth factors including vascular endothelial growth factor, proliferating nuclear cell antigen, Ki-67, vascular endothelial growth factor (VEGF), VEGF receptor (VEGFR) Flk-1 have been demonstrated in cerebrovascular malformations. Until now, in the relevant literature only two studies about anti-Ki-67 proliferating index (MIB-1) at cavernous hemangioma (CH) have been cited. However, these particular articles had no word on Ki-67 reactivity of endothelials cells in cavernous hemangioma. The mainstay of this study is definition of Ki-67 and p53 reactivity in cavernous hemangioma (CH), arteriovenous malformations (AVM) and capillary telangiectasia (CT). Paraffin embedded sections stained immunohistochemically with antibodies to Ki-67 and P53 in selected cases representing CH (n=14), AVM (n=11) and CT (n=2) were analyzed. Labeling indices for Ki-67 were found to be immunopositively reacting in endothelial cells of 5 cases of CH (45%) and 7 cases of AVM(50%). This findings emphasizes a remarklably higher ratio of proliferating cell pool in AVM than that of CH cases. From the point of understanding importance and impact of proliferating cell population in pathogenesis, a systematic investigation using a wide battery of antibodies for other molecular angiogenic factors should be applied for better understanding of these curious entities.

Authors and Affiliations

Ahmet MIDI, Aydin SAV, Turker KILIC, Necmettin PAMIR

Keywords

Langerhans Cell Histiocytosis and Intracranial Germinoma: Are Immunohistology Techniques Helpful in Distinguishing Two Entities?

Langerhans cell histiocytosis (LCH) is a clonal proliferative disease of the Langerhans cell. Langerhans cell bears abundant eosinophilic cytoplasm mainly associated with a matrix rich in eosinophils, mononuclear and mul...

EP ID EP154776
DOI -
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