Pathophysiological mechanisms of alcoholic myopathy - Lessons from rodent models
Journal Title: Journal of Veterinary and Animal Sciences - Year 2021, Vol 52, Issue 2
Abstract
Skeletal muscle dysfunction is highly prevalent and is one of the earliest pathological tissue changes among people with at-risk alcohol use. Clinical studies to elucidate pathophysiological mechanisms of alcohol-mediated muscle disease are hampered due to ethical considerations, and confounded by nutritional, lifestyle, and comorbid conditions. Rodent models have been developed to study the impact of at-risk alcohol consumption and alcohol-mediated end organ injury, including skeletal muscle dysfunction. This review discusses results from well-established rodent models of alcohol administration and highlights key pathophysiological mechanisms underlying alcoholic myopathy identified in rodent models. Salient pathways include impaired regenerative capacity, altered anabolic/catabolic balance, impaired mitochondrial bioenergetic function, and skeletal muscle morphological and contractile changes.
Authors and Affiliations
Danielle E. Levitt Patricia E. Molina Liz Simon
Keywords
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- EP ID EP699160
- DOI 10.51966/jvas.2021.52.2.107-116
- Views 74
- Downloads 0
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