Patient-Oriented Application of New Monoclonal Antibodies for Severe Asthma
Journal Title: Turkish Journal of Immunology - Year 2018, Vol 6, Issue 3
Abstract
Asthma is a chronic lung disease that occurs due to many genetic and environmental factors. In the Global Initiative for Asthma (GINA) guideline, anti-immunoglobulin E (anti-IgE) (omalizumab) for patients with allergic asthma, anti-interleukin-5 (mepolizumab and reslizumab) or anti-interleukin 5 receptor (benralizumab) for patients with severe eosinophilic asthma are recommended as add-on treatment if the patients remain uncontrolled on STEP-4 treatment. Omalizumab, a humanized monoclonal antibody, inhibits the immunologic effects of immunoglobulin E (IgE) that binds to circulating high affinity IgE receptor. Mepolizumab acts by binding to interleukin-5 (IL-5), a cytokine required for the development of eosinophils, and reduces eosinophil levels. Although the mechanisms of action are similar, the magnitude of the patient’s airway inflammation, the severity of the disease, and the phenotypic differences of the patients may be important for the treatment decisions. Even though in GINA, omalizumab is recommended as add-on treatment in STEP-5 for ≥6 years of age moderate to severe allergic asthma, in our country it was approved for the same phenotypic patients who were over 12 years of age. Both clinical trials and real world experience data support efficacy and safety of omalizumab for the treatment of moderate-to-severe allergic asthma. Evidence for clinical use in non allergic asthma as well as other investigational uses are already limited. Keywords: Asthma, immunoglobulin E, mepolizumab, omalizumab
Authors and Affiliations
Ender COŞKUNPINAR, Çağla TARIM, Ceyda HAYRETDAĞ ÖRS, İlkim DİNÇOL, Noor Muhammad MAKHDOMİ, Mohamed NİANG, Pınar YILDIZ
Keywords
Related Articles
- EP ID EP450960
- DOI 10.25002/tji.2018.858
- Views 90
- Downloads 0
Propolis Action in Controlling Activated T Cell Producing TNF-a and IFN-g in Diabetic Mice
Objective: This study was conducted to determine the suppressor effect of propolis in controlling activated T cells, also T cells expressing TNF-α and IFN-γ. Those molecules have an important role to generate acute infla...
Tinzaparin Tedavisinin Oral Yassı Hücreli Karsinoma Çıplak Fare Modelinde BAX ve CCNB1 Gen Anlatımları Üzerindeki Etkisi
The Effect of Tinzaparin Treatement on BAX and CCNB1 Gene Expression in an Oral Squamous Cell Carcinoma Nude Mice Model Introduction: This study aims to evaluate the effect of tinzaparin treatment on the expression of p...
Kronik Granülomatöz Hastalarında ve Bu Hastalığı Genetik Olarak Taşıyan Bireylerde Lenfosit Fonksiyonları
Introduction: Chronic granulomatous disease (CGD) is classically known as phagocytic system disease. However, in recent years, the observation of the development of autoimmunity, colitis-like findings during follow-up ha...
The Association Between Vitamin D Levels and Infections in Patients with Primary Immunodeficiency
ntroduction: Vitamin D is a hormone responsible in the regulation of immune response. This study was designed to assess the relationship of vitamin D deficiency on the development of infections in patients with primary i...
Prevalence of HLA-DQ*02 and HLA-DQ*08 in Patients with Celiac Disease in Eastern Anatolia and the Diagnostic Role of HLA-DQ*02 and HLA-DQ*08 Genotyping
Introducton: Celiac disease (CD) is diagnosed with serological tests and small bowel biopsy. There is a strong link between CD and human leukocyte antigens (HLA). In this study, we aimed to determine the role of HLA alle...