Pediatric nonalcoholic fatty liver disease
Journal Title: Jornal de Pediatria - Year 2019, Vol 95, Issue 1
Abstract
Nonalcoholic fatty liver disease (NAFLD) is a spectrum of fat-associated liver conditions that can result in end-stage liver disease and the need for liver transplantation. Simple steatosis, or fatty liver, occurs early in NAFLD and may progress to nonalcoholic steatohepatitis, which is characterized by the presence of hepatocellular damage such as lobular inflammation and cellular ballooning. It may evolve to fibrosis, and to cirrhosis with increased risk of hepatocellular carcinoma (HCC) in a variable proportion of cases. NAFLD is considered to be the hepatic component of metabolic syndrome (MetS),1 which also includes obesity, hypertension, dyslipidemia, impaired glucose regulation, and insulin resistance, and therefore represents a strong cardiovascular risk even at a very early age.2,3
Authors and Affiliations
Claudio Chiesa
Keywords
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- EP ID EP494270
- DOI 10.1016/j.jped.2018.05.001
- Views 66
- Downloads 0
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