Performance of osteoporosis self-assessment tool in detecting low bone mineral density in menopausal women
Journal Title: Universa Medicina - Year 2017, Vol 36, Issue 2
Abstract
Background The osteoporosis self-assessment tool (OST) is a simple screening tool to assess risk of osteoporosis and to select high risk women for dual-energy x-ray absorptiometry (DXA) examination. This study aimed to evaluate OST performance in detecting low bone mineral density (BMD) in menopausal women. Methods A cross-sectional study involving 60 menopausal women aged 50-65 years. The OST score was calculated from: [weight (kg) – age (yr)] x 0.2. Subjects were classified by OST score into low risk (OST ³2) and high risk (OST< 2) groups. BMD was determined by DXA at 3 bone locations (L1-L4, femoral neck, and total hip). DXA T-scores were categorized into: normal BMD (T-score >-1) and low BMD (T-score £-1). Independent t-test was used to compare subject characteristics between OST groups. Diagnostic performance of OST was evaluated by measuring sensitivity, specificity, positive & negative predictive value (PPV, NPV), positive & negative likelihood ratio (PLR, NLR) and receiver-operating characteristic (ROC). Significance was set at p<0.05. Results Subject characteristics and BMD between groups were significantly different (p<0.05). Most subjects (44/73.3%) had high risk of low BMD (OST < 2). Low BMD (T score £-1) was found in 43 subjects (71.7%) at L1-L4, 41 subjects (68.3%) at femoral neck, and 37 subjects (61.7%) at total hip. Diagnostic performance of OST was significant at total hip BMD (sensitivity=0.946, AUC=0.777). Conclusion We conclude that use of the OST score in menopausal women is effective and has adequate sensitivity and specificity. The highest diagnostic performance of OST is on total hip BMD.
Authors and Affiliations
Ignatio Rika Haryono, Nawanto Agung Prastowo
Keywords
Related Articles
- EP ID EP376436
- DOI 10.18051/UnivMed.2017.v36.123-130
- Views 342
- Downloads 0
Increase in neutrophil count after repeated exposure of Plasmodium berghei-infected mice to artemisinin
Background Leukocytes play an important role in the elimination of malaria infection. The leukocyte profile upon elimination of the malaria parasites that have been exposed to antimalarials and are subsequently capable o...
Imminent threat of antibiotic resistance and the importance of diagnostic and antibiotic stewardship
Antibiotic is one of the hallmarks of modern medicine. Antibiotics have saved many lives that was unthinkable prior to the discovery of antibiotic. Yet, antibiotic use is associated with the danger of resistance of bacte...
Tumor necrosis factor-α-activated mesenchymal stem cells accelerate wound healing through vascular endothelial growth factor regulation in rats
Background Wounds are areas of physical or thermal damage of the epithelial layer of skin or mucosa. The wound healing process consists of hemostasis, inflammation, proliferation, and remodeling. Mesenchymal stem cells (...
High ferritin in homozygous and heterozygous β-thalassemia tends to decrease oxidative stress levels
Background Ineffective erythropoiesis and multiple blood transfusions may cause iron overload, leading to high level of ferritin in β-thalassemia patients. Iron has the ability to catalyze the production of reactive oxy...
Zinc deficiency as risk factor for stunting among children aged 2-5 years
Background Stunting is a nutritional problem in the form of linear growth disturbance caused by low intake of macro- and micronutrients. The prevalence of stunting in children aged 2-5 years in Semarang is higher in wel...