Personalized approaches to the primary prevention of cardiovascular diseases
Journal Title: Український терапевтичний журнал - Year 2019, Vol 0, Issue 2
Abstract
Objective — to evaluate the anthropometric indices, the level of blood lipids, as well as their dynamics in the course of modifying of lifestyle in individuals with different variants of polymorphic loci of beta-adrenergic receptor genes. Materials and methods. The study included 110 subjects with moderate and high cardiovascular risk. Blood pressure, height, weight, and body composition (Body Composition Monitor BF511, Omron) were determined. To assess the physical activity, the questionnaire «International Questionnaire on Physical Activity» was used. A patient was given individualized recommendations for the extension of physical activity developed using the computer program «Metabolism» (Lytech Research and Production Company, RF) based on genetic testing. The level of total cholesterol and its fractions was determined by the enzymatic method (HumaStar 200 analyzer). Genotyping of polymorphic sites of genes ADRB2 (Gln27Glu, C531G, rs1042714 and Agr16Gly, A46G, rs1042713) and ADRB3 (Trp64Agr, T190C, rs4994) was carried out by real-time polymerase chain reaction (SNP-Express-SHOT reagent kit (Lytech Research and Production Company)). For allelic discrimination, CFX Manager Software was used. Statistical analysis was performed using SPSS 17.0 software. Results and discussion. It has been established that carriers of the CC genotype of the polymorphic locus C531G of the ADRB2 gene, the AA + AG genotype of the polymorphic locus A46G of the ADRB2 gene, and the TC genotype of the T190C polymorphism of the ADRB3 gene had lower proportion of muscle tissue. The increased physical activity in carriers of the AA+AG genotypes of the polymorphic locus A46G of the ADRB2 gene and TT of the T190C locus of the ADRB3 gene was associated with a significant decrease in the proportion of adipose tissue, and increase in the proportion of muscle tissue. With the extension of physical activity, there was a significant decrease in low density lipoprotein cholesterol (LDL cholesterol) in carriers of the TT genotype of the T190C polymorphism of the ADRB3 gene and the AA + AG genotypes of the A46G polymorphic locus of the ADRB2 gene. Carriage of AA + AG genotypes of the polymorphic locus A46G of the ADRB2 gene is associated with a decrease in the proportion of adipose tissue (p = 0.032) and LDL cholesterol (p = 0.034). Conclusions. The carriage of the AA + AG genotypes of the polymorphic locus A46G of the ADRB2 gene and the TT genotype of the locus T190C of the ADRB 3 gene is associated with a significant decrease in the proportion of adipose tissue and an increase in the proportion of muscle tissue with increased physical activity. A significant reduction in the level of low-density lipoprotein cholesterol was found in carriers of the TT genotype of the T190C polymorphism of the ADRB3 gene and the AA+AG genotypes of the A46G polymorphic locus of the ADRB 2 gene.
Authors and Affiliations
G. D. Fadieienko, G. S. Isayeva, V. Yu. Halchinska, Т. M. Bondar
Keywords
Related Articles
- EP ID EP624158
- DOI 10.30978/UTJ2019-2-14
- Views 113
- Downloads 0
Investigation of a new indicator of autoimmune accumulation in the genesis of type I diabetes mellitus
Objective — the search for the new marker of autoimmune accumulation in the genesis of type I diabetes mellitus (DM-1). Materials and methods. With the use of immune enzymatic assay, investigations have been performed of...
Health aging: medicalbiological and socioeconomic aspects
The review is devoted to the discussion of population, biomedical and socioeconomic aspects of aging. The data have been presented on the demographic situation in the world, due to the rapid growth of aging in the XXI c...
Macrophage migration inhibitory factor and acute myocardial infarction
Macrophage migration inhibitory factor (MIF) is a pleiotropic proinflammatory cytokine involved in the development of many acute and chronic inflammatory diseases, including cardiovascular diseases. A link between MIF a...
The effects of prolactin on ADP-induced platelet aggregation in patients with stable angina of effort and gastroesophageal reflux disease
The combination of stable angina of effort (SEA) and gastroesophageal reflux disease (GERD) is frequently observed in the clinic of internal diseases. Thrombocytic link of homeostasis is one of the main factors in the de...
Peculiarities of the psychoemotional condition of respondents with vegetative dysfunction on the example of the medical university students
Objective — to identify the frequency and clinical psychopathological peculiarities of the psychoemotional state of the entrants of the Vinnytsia National Medical University (VNMU) named after M.I. Pirogov. Materials an...