PHARMACEUTICAL TECHNIQUES FOR THE FABRICATION OF POOR WATER SOLUBLE DRUGS – A REVIEW
Journal Title: Baqai Journal of Health Sciences - Year 2018, Vol 21, Issue 1
Abstract
Pharmaceutical technologies for increasing the solubility of drug substances have a prime role in its faster dissolution and maximum absorption in the systemic circulation. Majority of the drugs possesses low solubility leading to poor absorption and erratic bioavailability and thus failed to achieve a desired pharmacological response. Therefore formulation scientists have adopted various techniques to overcome solubility and bioavailability issues following oral administration. The selection of technique is primarily based on the physicochemical characteristics of drug and dosage form. The present review highlights the importance of solubility with a brief description of conventional and novel approaches that could be used for solubility enhancement.
Authors and Affiliations
Rabia Noor, Syed Muhammad Farid Hasan, Farah Khalid
Keywords
Related Articles
- EP ID EP302773
- DOI -
- Views 107
- Downloads 0
A RARE PRESENTATION OF MULTIPLE HYDATID CYST ON EITHER SIDE OF DIAPHRAGM
Cystic echinococcosis (CE) or more commonly known as hydatid cyst is a zoonotic infection caused by Echinococcus granulosus. Although the two most common locations of hydatid cyst are liver and lungs, it may appear in an...
SEROPREVALENCE OF HEPATITIS C AMONG THE APPARENTLY HEALTHY BLOOD DONORS OF KARACHI
Hepatitis C is a global health issue. Pakistan is among the prevalent countries for hepatitis C virus (HCV). Due to poverty, unemployment, low literacy rate, unawareness and poor health facilities, Pakistani population a...
DEVELOPMENT, VALIDATION AND KINETIC APPLICATION OF SPECTROMETRIC METHODS FOR THE ANALYSIS OF ASPIRIN, SALICYLIC ACID, AND CAFFEINE AS SINGLE-COMPONENT AND IN MIXTURES
Aspirin (ASA) and aspirin-caffeine dosage forms are widely used as analgesic drugs. In the present study specific stability-indicating two- and three-component spectrometric methods have been developed for the assay of A...
EFFECTS OF NUTRITION AND PARENTING STYLE ON CHILD DEVELOPMENT AT THE AGE OF 3–5 YEARS
Child development is basically the changes that occur in children from various aspects. The development is influenced by both internal factors (such as genetics and hormonal) as well as environmental and parental stimula...
COMPARISON OF EFFICACY OF ACECLOFENAC WITH DICLOFENAC SODIUM FOR POSTOPERATIVE PAIN RELIEF FOLLOWING LAPAROSCOPIC CHOLECYSTECTOMY
The object of the present study was to compare the efficacy of intramuscular injections of aceclofenac with diclofenac sodium for postoperative pain relief following laparoscopic cholecystectomy. The study was carried ou...