Pharmacodynamic Modeling of Sequence-Dependent Antitumor Activity of Insulin-like Growth Factor Blockade and Gemcitabine
Journal Title: The AAPS Journal - Year 2012, Vol 14, Issue 1
Abstract
The online version of this article (doi:10.1208/s12248-011-9308-3) contains supplementary material, which is available to authorized users.
Authors and Affiliations
Amit Khatri, Richard C. Brundage, Jessica M. Hull, Brent W. Williams, Douglas Yee, Mark N. Kirstein
Keywords
Related Articles
- EP ID EP681183
- DOI 10.1208/s12248-011-9308-3
- Views 80
- Downloads 0
Effects of protein aggregates: An immunologic perspective
The capacity of protein aggregates to enhance immune responses to the monomeric form of the protein has been known for over a half-century. Despite the clear connection between protein aggregates and antibody mediated ad...
Role of Organic Anion-Transporting Polypeptides (OATPs) in Cancer Therapy
The superfamily of organic anion-transporting polypeptides (OATPs, gene symbol SLCO) includes important transporters handling a variety of endogenous and xenobiotic substrates. Currently, 11 human OATPs are known and the...
Unbiased membrane permeability parameters for gabapentin using boundary layer approach
The present study was performed to determine the relative contribution of both passive and nonpassive transport processes in jejunal absorption of gabapentin. The oral absorption of gabapentin was studied using in situ s...
A One-Step Solid Phase Extraction Method for Bioanalysis of a Phosphorothioate Oligonucleotide and Its 3′ n-1 Metabolite from Rat Plasma by uHPLC–MS/MS
Oligonucleotide therapeutics have emerged as a promising class of drugs to treat a wide range of diseases caused by genetic abnormalities. Replacement of the phosphodiester linkage with a phosphorothioate is one of the m...
Re-introduction of a Novel Approach to the Use of Stable Isotopes in Pharmacokinetic Studies
The purpose of this investigation is to evaluate the scientific benefits of a novel approach in using stable isotopes to reduce the number of subjects needed to perform relative bioavailability and bioequivalence pharmac...