Pharmacological evaluation of Streblus asper Lour. (Shakhotaka) extract with special reference to Antioxidant and Hypoglycemic activities
Journal Title: IOSR Journal of Biotechnology and Biochemistry (IOSR-JBB - Year 2018, Vol 4, Issue 5
Abstract
Diabetes mellitus (DM) is a metabolic disorder of multiple etiologies characterized by absolute or relative deficiency of insulin secretion with or without varying degree of insulin resistance. Sedentary life style and obesity are two major epidemiological determinants of diabetes mellitus. In the present investigation hypoglycemic and antioxidant efficacy of methanol extract of Streblus asper of family Moraceae was tested on STZ induced mice diabetic models. The results clearly indicated that the diabetic control (DC) mice presented a significant lowering of body weight (p<0.001) when compared with the normal control (NC) mice. The DC mice showed a significantly (p<0.001) higher level of glucose (+279%), when compared with their normal control counterparts. Diabetic mice of all the three groups (DT150, DT250 and DT500) showed a reduction in glucose levels, when compared to the DC ones. The results clearly indicated that the methanol extract of Streblus asper is antidiabetic in nature due to the presence of different types of active phytochemicals. The role of oxidative stress in the patho-physiology of diabetes and its associated complications are well known. The antioxidant system plays an important role in defending the cells against oxidants generated during metabolic processes and thus prevents the tissues from toxic response of the oxidants. The methanol extract of Streblus asper exhibited anti diabetic property as well as increased the levels of enzymatic and non enzymatic anti oxidant entities along with reduced MDA levels. The methanol extract of this plant did not exhibit any toxicity in the present study and thus it was concluded that the extract possesses antidiabetic as well as antioxidant properties without any adverse effect.
Authors and Affiliations
Pratima Kumari, Santwana Rani, Aman Kumar, Baidyanath Kumar
Keywords
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- EP ID EP415152
- DOI 10.9790/264X-0405011425.
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