Phenotypic Detection of Prevalence of Carbapenemase Producing Enterobacteriaceae Isolates in a Tertiary Care Hospital,Rims, Ranchi.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 2
Abstract
Introduction – The Modified Hodge test (MHT) detects carbapenemase production in isolates of Enterobacteriaceae. It is detected when the test isolate produces the enzyme and allows growth of a carbapenem susceptible strain (E.coli ATCC 25922) towards a carbapenem disk producing a characteristic cloverleaf-like indentation [1]. Aims and objectives – To evaluate the epidemiology of carbapenemase producing Enterobacteriaceae isolates in a tertiary care hospital, RIMS, Ranchi. Methodology – A total of 678 isolates belonging to the family Enterobacteriaceae were obtained over a period of 6 months. Amongst these, 201 showed intermediate or resistant zone of inhibition for Meropenem(10µg) disk, which were selected for further processing by MHT. Results and Discussion – 23.15% (157) of the total (678) and 78.10% of those which showed intermediate or resistant zone of inhibition, gave positive results for MHT. Conclusion – Enterobacteriaceae members are among the most common and easily transferable species causing nosocomial infections [2]. Hence, it will be helpful in preventing the spread of resistant strains, if MHT is incorporated in routine practice.
Authors and Affiliations
Manoj Kumar, Neha . , Ashok kr. Sharma, Amber Prasad
Keywords
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- EP ID EP467562
- DOI 10.9790/0853-1802091924.
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