Phenotypic Profile of Kell Blood Group System among Saudi Donors at King Abdulaziz Medical City-Riyadh
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 1
Abstract
Background: The Kell blood group system (KBGS) is complex and contains many blood group antigens; these antigens are considered highly immunogenic. KBGS antigens are the third most potent, after the ABO and Rh blood group antigens. Aims: The aim of this study is to provide essential data about the distribution of the major Kell antigens and the most common phenotype among the Saudi population. Methodology: This is a retrospective study to evaluate the Kell antigens grouping performed among some donors who donated blood or blood products at department of donation center in King Abdulaziz Medical City, Riyadh, Saudi Arabia from 1st January 2015 to 31th December 2015. Sample size included four hundred donors. All donors are males and their ages were above 18 years. Results: The Incidence of other kell antigens i.e. K, k, Kpa and Kpb were 18.2%, 97.0%, 11.7% and 96.0% respectively The most common kell phenotype according to K and k antigens among Saudi donors was K-k+ (81.5%) followed by K+k+ (15.5%) followed by K+k- (3%) and the K-k- phenotype was (0%) , while the most common kell phenotype according to Kpa and Kpb antigens among Saudi donors was Kpa - Kpb+ (88.0%) followed by Kpa +Kpb + (7.8%) followed by Kpa +Kpb -(4.2%) and the Kpa -Kpb - phenotype was (0%). Conclusion: This study showed that there is a wide racial and geographical variation in the distribution of Kell antigens and phenotypes among study participants. The Kell blood group system has vital role in population genetic study and in resolving medical-legal issues and more importantly in transfusion medicine practice
Authors and Affiliations
Mohieldin Elsayid
Keywords
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