Phenytoin induced dress syndrome
Journal Title: International Journal of Allied Medical Sciences and Clinical Research - Year 2016, Vol 4, Issue 3
Abstract
Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) Syndrome may cause a serious hypersensitivity reaction to anti-epileptic drugs, such as phenytoin and carbamazapine drugs. DRESS syndrome symptoms include rash, fever, lymphadenopathy, eosinophilia, cutaneous eruption and potentially life-threatening damage of one or more organs such as nephritis, myocarditis or hepatitis. We report a 60 year old female patient was admitted in the hospital with the chief complaints of ulceration of mouth&lips, high fever, weakness, whitish papules on the hard palatal mucosa, patches of dryness in nasolabial folds and rashes on the whole body. Her past medical history was found to be late onset of epilepsy and hypertension since one month. Her medication history is she was taking Eptoin (phenytoin) 100mg thrice daily, C-Zam (Clobazam) 10mg, twice daily. Blood tests show elevated levels of neutrophils, eosinophils, erythrocyte sedimentation rate (ESR) and liver enzymes such as SGOT, SGPT, Alkaline phosphatase. Decreased levels of lymphocytes, PCV, MCV and MCH. The patient was diagnosed as DRESS syndrome, according to RegiSCAR score. Phenytoin was discontinued and replaced by Clobazam and corticosteroids and vitamin supplement were prescribed. Finally a good response to the treatment was observed.
Authors and Affiliations
Dadi G. V. S. Surya Chandini
Keywords
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