PHYSICAL APPROACH TO TRANSDERMAL DRUG DELIVERY: A REVIEW
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2017, Vol 7, Issue 3
Abstract
Transdermal drug delivery system (TDDS) is the topically administered medication, which when applied to the skin, delivers the drug through the skin for systemic effect at a predetermined and controlled rate. For the drugs, having the short biological half-life, transdermal drug delivery system is convenient. It overcomes the problems like the hepatic first pass effect, improves the compliance of patients, decreases the administration frequency, and reduce the gastrointestinal side effects, peak and valley levels in the blood are avoided. Due to having an advantage of being non-invasive, this delivery has to fulfill some parameters such as high potency, better permeability through skin and non-irritation for better compliance. Skin serves as a site of drug application for local effect as well as systemic effect. There are wide varieties of drugs for which topical or transdermal is a viable option, skin penetration enhancement techniques have been developed for such drugs. There are a number of physical methods to increase drug delivery via the skin, many of which require the use of devices and some of which hold the promise to significantly expand the spectrum of drugs that can be administered transdermally to include water-soluble molecules and macromolecules. Iontophoresis and electroporation represent electrically assisted, physical approaches to enhance delivery of drugs/macromolecules across the stratum corneum. This review highlights the detailed role of physical penetration and describes their mechanism of action.
Authors and Affiliations
Neha Jawale
Keywords
Related Articles
- EP ID EP295508
- DOI 10.22270/jddt.v7i3.1435
- Views 116
- Downloads 0
EXPERIMENTAL STUDY TO EVALUATE THE ANTINOCICEPTIVE ACTIVITY OF FLUOXETINE AND ITS INTERACTION WITH NALOXONE AND ONDENSETRON IN MICE
Objectives: Evaluate antinociceptive activity of fluoxetine and the interaction of fluoxetine with naloxone and ondansetron. Methods: 32 albino mice of either sex were divided into 4 groups of 8 mice each: group I receiv...
Application of ImageJ for processing Shilajit exposed PBMC images
Objective: In this study, application of ImageJ for processing Shilajit exposed PBMC images were studied. Methods: In present study experiment was designed with human PBMC treated with Shilajit in high concentration (18...
WOUND REPAIR AND REGENERATING EFFECT OF EUGENOL ISOLATED FROM ETHYL ACETATE SOLUBLE FRACTION OF ETHANOLIC EXTRACT OF CINNAMOMUM TAMALA LEAVES IN STZ DIABETIC RATS
Diabetes is a chronic hyperglycaemic disorder; leads to developed several complications including delayed wound healing after any injury. These non-healing wound ends up to organ or limb salvage. The available modern med...
EVALUATION OF PHYSICOCHEMICAL STANDARDIZATION PARAMETERS OF SOLENA AMPLEXICAULIS LEAF
Solena amplexicaulis, commonly called as the creeping cucumber, belongs to the family Cucurbitaceae. Traditional it is used as astringent, appetizer, carminative, cardiotonic, digestive, diuretic, expectorant, invigorati...
Development and validation of novel HPLC method for the estimation of Rutin in crude hydromethanolic leaf extract of Prosopis cineraria
A simple, specific, accurate and precise high performance liquid chromatography method has developed for the estimation of rutin in Prosopis cineraria. The chromatographic separation was achieved by using C18 column, 150...