PHYSICAL CHARACTERISTICS AND STABILITY MUCOADHESIVE MICROGRANULES OF RANITIDINE HCL WITH ALOE VERA POWDER POLYMER AND CARBOPOL 934P IN TEMPERATURE 2°C AND 25°C
Journal Title: World Journal of Pharmaceutical and life sciences - Year 2018, Vol 4, Issue 4
Abstract
Ranitidine HCl has low stability due to its hygroscopic. Stability tests need to determine the changes physical and chemical stability that occur during storage against. A study was conducted to determine the effect of storage temperature (2°C and 25°C) on the stability of the mucoadhesive microgranules ranitidine HCl over a period of 3 months. The mucoadhesive polymer used was a combination of aloe vera powder and carbopol 934P. Aloe vera powder was made by dried process using freeze dryer at -45ºC. The method of making granules used is wet granulation. The parameters tested included moisture, flow rate, flux, mucoadhesive power in vitro, dissolution, permeation, and SEM (Scanning Electron Microscopy). Data analysis using Statistic Product and Service Solution (SPSS) 16.0 with one way ANOVA test. The test results was showed that temperature and storage time affect the stability of microgranules because the release rate constant is significantly different throughout the test. Storage of microgranules stable at 2°C, because from 0 to 3 months which shows different results are not significant.
Authors and Affiliations
Endang Diyah Ikasari
Keywords
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