Physical development as an integral indicator of rehabilitation of patients with type 1 diabetes mellitus
Journal Title: Український журнал дитячої ендокринології - Year 2019, Vol 0, Issue 2
Abstract
The objective of the study was to determine the characteristics of physical development of adolescents with type 1 diabetes mellitus, in the current conditions of medical care. Materials and methods. A comprehensive survey was carried out of 48 boys and 22 girls 12—17 years of age with type 1 diabetes mellitus (T1DM) on the determination of anthropometric indices, an assessment of the nature of physical development (PD) and the status of carbohydrate metabolism based on glycosylated hemoglobin: < 6.05 % — the ideal level of compensation was diagnosed, from 6.05 % to < 7.6 % — optimal, 7.6 % — 9.0 % — suboptimal, > 9.0 % — with a high risk for life. Mathematical processing of the results of the survey of adolescents was carried out using SPSS Statistics 17.0 and Excel software packages. Results and discussion. It was found that 60.0 % of the subjects had disharmonious PD, mainly due to high stature and body weight deficiency. Frequency and structure of PD disturbances were affected by the compensation of carbohydrate metabolism and age, in which the T1DM manifestation took place. The disharmonic PD was more likely to be observed in adolescents with poor levels of compensation (76.3 %) than with the optimal (38.5 %; p1 < 0.05) and suboptimal one (52,6 %; p2 < 0,05). Patients with suboptimal control were most often diagnosed with high stature (26.3 %) and body weight deficiency (15,8 %). In decompensated diabetes, there were more patients with body weight deficiency (18.4 %) and overweight (10.5 %). In adolescents with a manifestation of the disease in childhood (30.0 %) and in preadolescence (21.4 %), disharmonic PD was significantly more likely to be detected than in patients with adolescent-onsetT1DM (8.6 %; p1 < 0,05 and p2 < 0.05). Conclusions. The risk group for the formation of disharmonious PD is teenagers with insufficient compensation of carbohydrate metabolism and patients with the onset of T1DM in childhood and preadolescence.
Authors and Affiliations
S. I. Turchina, L. D. Nikitina, L. P. Levchuk, O. I. Yudchenko
Role of TaqIA genetic polymorphism of D2 dopamine receptor gene, level of leptin and dopamine in blood in development of various types of obesity in children
Objective — to evaluate the role of TaqIA genetic polymorphism of D2 dopamine receptor gene, neuropeptides (leptin, dopamine) level in blood in development of excess body weight in children with various forms of obesity....
Y chromosome in female patients with a clinical diagnosis of Turner syndrome: literature review and researchers’ own monitoring
Turner syndrome (TS) is the most common genetic disorder associated with X chromosome abnormality. Total absence of one of the X chromosomes in all cells occurs in 40—50 % of cases. In 5 % of female patients with TS ther...
Optimization of somatotropin dose during treatment of children before puberty with the syndrome of bioinactive growth hormone
Objective — to study effectiveness and safety of applying various doses of recombinant growth hormone (rGH) during treatment of children before puberty with the syndrome of bioinactive growth hormone (SBGH) in order to i...
Correction of immunologic responsiveness as a part of comprehensive treatment in adolescents with unfavorable course of diffuse nontoxic goiter living under conditions of mild iodine deficiency
Objective — to determine the role of correction of immune status disorders in treatment of adolescents with unfavorable course of diffuse nontoxic goiter (DNG). Materials and methods. We have assessed somatic health sta...
Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency an Endocrine Society. Clinical practice guideline. Part 1
-