PHYSIOLOGICAL AND BIOCHEMICAL MARKERS TO ASSESS THE RISK FACTORS FOR DIABETIC NEPHROPATHY: A RETROSPECTIVE RURAL HOSPITAL BASED CASE CONTROL STUDY
Journal Title: Journal of Biological and Scientific Opinion - Year 2014, Vol 2, Issue 1
Abstract
Diabetic nephropathy (DN) is a major contributor to chronic kidney diseases globally as well as in India andis associated with increased cardiovascular risk. The aim of this study is to estimate HbA1c, Fasting Insulin, total lipid profile, renal parameters and anthropometric parameters in assessing the most common complications of Diabetic Nephropathy. Two hundred fifty type 2 diabetes mellitus and non-diabetes subjects were studied for their anthropometric and biochemical parameters. Independent paired t-test was used to compare mean differences between parameters and p-value < 0.05 was considered significant. Diabetic patients had higher BMI, WHR and higher insulin levels compared to non- diabetics. Significant relation was observed between HbA1c and HDL-C in diabetic patients. Higher values of fasting insulin, HbA1c, lipid profile with anthropometric measurements and other biochemical parameters were significantly associated with commonest conflict of diabetic nephropathy. It further predicts CVD mortality in patients with diabetic nephropathy. Early screening for incipient diabetic nephropathy and aggressive management of these risk factors is important in optimizing the renal outcome of patients with diabetes mellitus. These results indicate that the risk of developing diabetes is certainly higher in non-diabetes subjects.
Authors and Affiliations
Raja Reddy , Shashidhar KN, Karthiyanee Kutty, Lakshmaiah V
Keywords
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- EP ID EP104747
- DOI 10.7897/2321–6328.02105
- Views 90
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