PHYSIOLOGICAL ASPECTS OF PAIN SENSITIVITY
Journal Title: International scientific journal Science and Innovation - Year 2024, Vol 3, Issue 4
Abstract
The article describes the pathophysiological mechanisms of the formation and development of somatogenic and neurogenic pain syndromes. The pathophysiological and neurochemical aspects of hyperalgesia are considered. The results of immunohistochemical studies of the participation of excitatory amino acids, neuropeptides, nitric oxide, and Ca2+ ions in the mechanisms of sensitization are presented. The structural aspects of neurogenic pain syndromes are the formation in the central nervous system of aggregates of interacting sensitized neurons with impaired inhibitory mechanisms and increased excitability. Scientists associate the features of the pathogenesis of somatogenic and neurogenic pain syndromes with the principles of therapy for pathological pain
Authors and Affiliations
Pazilova Sevara Bakievna
Keywords
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- EP ID EP735573
- DOI 10.5281/zenodo.11097936
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