PHYTO SOMES: A NOVEL PHYTO-PHOSPHOLIPID CARRIERS FOR HERBAL DRUG DELIVERY
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 6
Abstract
Advanced biochemical and pre-clinical studies have proved the potential of plant flavonoids, polyphenolics and other hydrophilic natural compounds for the treatment of skin disorders, different types of carcinoma, anti-aging and many other areas of therapeutics and preventive medicine. The hydrophilic nature and unique chemical structure of these compounds pose major challenge because of their poor bioavailability through the skin or gut. The bioavailability can be improved by the use of delivery systems, which can enhance the rate and the extent of drug solubilizing into aqueous intestinal fluids as well as the capacity to cross the lipid rich biomembranes. Phospholipid based drug delivery systems have been found promising for the effective and efficacious herbal drug delivery. Complexing the polyphenolic phytoconstituents in molar ratio with phosphatidylcholine results into a new herbal drug delivery system- "Phytosome". Phytosomes show better pharmacokinetic and therapeutic profile than conventional herbal extracts.
Authors and Affiliations
Pandu Thurapati , Srikanth Mettu , Prabhakar Veerareddy
Keywords
Related Articles
- EP ID EP108529
- DOI -
- Views 108
- Downloads 0
MARKETED PREPARATIONS: QUALITY EVALUATION OF DELAYED RELEASE ASPIRIN TABLET
The main purpose of this work was quality evaluation of several delayed release marketed preparations. Extended release dosage forms are designed to achieve a prolonged therapeutic effect by continuously releasing drug o...
PHRMACOGNOSTICAL AND PHARMACOLOGICAL SCREENING OF TRIDAX PROCUMBENS L.
Pharmacognostical parameters for the leaves of Tridax procumbens L. (Family- Asteraceae) were studied with the aim of drawing the pharmacopoeial standards for this species. Macroscopical and microscopical characters, phy...
SIMULTANEOUS SPECTROPHOTOMETRIC ESTIMATION OF IRBESARTAN AND HYDROCHLOROTHIAZIDE IN TABLETS
Two simple, sensitive, rapid, accurate and economic spectrophotometric methods were developed for the estimation of Irbesartan and Hydrochlorothiazide in two-component solid dosage form. First method is based on the simu...
DILTIAZEM HCL: EVALUATION OF IT’S PRESENCE IN BANGLADESH
Diltiazem hydrochloride is a calcium channel blocker used for the treatment of chronic stable angina pectoris as well as for angina pectoris caused by a coronary arterial spasm and systemic hypertension. In spite of thes...
EFFECT OF AQUEOUS EXTRACT OF PUNICA GRANATUM FLOWER ON BIOMARKERS AND ECG CHANGES IN ISOPROTERENOL INDUCED MYOCARDIAL INFARCTION IN RATS
The present study was designed to investigate the effect of aqueous extract of Punica granatum flower (PG) against isoproterenol (ISO) induced myocardial infarction (MI) in rats by studying cardiac markers and electrocar...