Phytochemical Analysis and Evaluation of Antidiabetic Activity of Rhus aromatica Mother Tincture by Invitro Methods
Journal Title: Scholars Academic Journal of Pharmacy - Year 2018, Vol 7, Issue 7
Abstract
Abstract: Diabetes is a clinical syndrome characterized by hyperglycemia due to absolute or relative deficiency of insulin. Rhus aromatica is a deciduous shrub in the family Anacardiaceae native to Canada and the United states. The aim of the current study was to screen the Rhus aromatica mother tincture for its in vitro antidiabetic activity. One antidiabetic therapeutic approach is to reduce gastrointestinal glucose production and absorption through the inhibition of carbohydrate digesting enzymes such as α- amylase and α-glucosidase. Inhibition of amylase and glucosidase enzymes involved in digestion of carbohydrates can significantly decrease the post prandial increase of blood glucose after a mixed carbohydrate diet and therefore can be an important strategy in management of blood glucose. Free radicals are atoms or molecules that have at least an unpaired electron in their outer most shell or orbital,which are not contributing to molecular bonding and are capable of independent existence. Free radicals involving oxygen atoms are known as reactive oxygen species (ROS). In diabetic complication free radicals are generated, some of the most important ROS and RNS in vascular cells. The main characteristic of an antioxidant is its ability to trap free radicals. Highly reactive free radicals and oxygen species can initiate degenerative diseases. The best described pharmacological property of flavonoids is their capacity to act as potent antioxidant that has been reported to play an important role in the alleviation of diabetes mellitus. Antioxidant compounds like phenolic acids, polyphenols and flavonoids are commonly found in plants have been reported to have multiple biological effects, including antioxidant activity. The antioxidant potential of Rhus aromatica mother tincture was examined by DPPH free radical scavenging assay, nitric oxide (NO) free radical scavenging assay and Hydrogen peroxide free radical scavenging assay.
Authors and Affiliations
Deepa P, Jayachandran TP
Keywords
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