Phytochemical And Antimicrobial Properties of Leaf Extracts of Lupinus Arboreus (Yellow Bush) Against Dental Caries Pathogens.
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 3
Abstract
The quests for novel antimicrobial agents from medicinal plants to combat pathogens have become crucial for avoiding the emergence of untreatable microbial infections and reduce the use of synthetic chemicals against these microorganisms. The antimicrobial effect of the crude leaf extract and fractions of (yellow bush) Lupinus arboreus on dental caries pathogens was investigated. The crude water extract of the fresh leaves was obtained by cold maceration, sieved, decanted and evaluated using modified agar-well diffusion method; while the pulverized dried leaves extract was fractionated into ethanol, methanol and Hexane fractions, obtained by 48hours cold maceration and evaluated using modified agar-well diffusion method. The results showed that the crude water extract and fractions at varying concentrations, exerted strong antimicrobial activity on some of the test organisms. However, a weak activity was observed on the tested fungi Candida albicans. Methanol and ethanol fractions showed the highest activity on many organisms than the Hexane fraction. The phytochemical studies showed that the extract had the abundance of Saponins, Glycosides, Steroids, Terpenes and Flavonoids. Resins, protein and reducing sugar occurred in moderate amounts, while alkaloids appeared but in trace amount. The pH of the crude extract was determined as 2.90.
Authors and Affiliations
Nwankwo, Joseph I, Egede, Malachy Ugochukwu
Keywords
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- EP ID EP384967
- DOI 10.9790/3008-1103047987
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