PHYTOCHEMICAL AND ANTIOXIDANT PROPERTIES OF MANILKARA ZAPOTA (L.) P ROYEN FRUIT EXTRACTS AND ITS FORMULATION FOR COSMECEUTICAL APPLICATION
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2018, Vol 5, Issue 3
Abstract
Manilkara zapota (L.) P fruit extracts were investigated for its bioactive compounds and their potential of natural antioxidant properties for cosmeceutical application. In vitro antioxidant activity of hexane, ethyl acetate, and ethanol extracts were evaluated by 1,1-diphenyl- picrylhydrazyl (DPPH) radical scavenging activity, ß-carotene bleaching activity assays (BCB) and oxygen radical absorbance capacity (ORAC) methods. Total phenolic (TPC), total flavonoid (TFC) and total tannin (TT) of the extracts were determined. Antioxidant activity by DPPH scavenging activity has a good correlation with phenolic and flavonoid content R2= 0.9905 and R2= 0.9924. Whereas, no correlation was shown between ORAC and TPC values (R2 < 0.1). Liquid chromatography mass spectrometry (LCMS) was used to analyze the amount of targeted phenolic and fatty acids in EtPE, EaPE and ethyl acetate seed extract (EaSE). EaPE and EtPE extracts demonstrated strong antioxidant activity than HSE (3.09±0.08 μg/mL, 2.57±0.18 μg/mL and 7.54±0.17 μg/mL (p<0.05), respectively). However, EtPE extract was chosen to be formulated and studied as ethanol is much cheaper than ethyl acetate as solvent for extraction. The formulation exhibited non-toxic property and thus safe to be explored in cosmeceutical application.
Authors and Affiliations
Ziti Akhtar Shafii
Keywords
Related Articles
- EP ID EP635573
- DOI -
- Views 148
- Downloads 0
EFFECT OF MORIN ON PERPHENAZINE INDUCED PSEUDO-PARKINSONISM IN RAT
Parkinson’s disease (PD) is a common neurodegenerative disease characterized by progressive loss of midbrain dopaminergic neurons. Morin has been shown to exert neuroprotective and anti-oxidant effects in different model...
APPLICATION OF TLC DENSITOMETRIC AND UV SPECTROPHOTOMETRIC TECHNIQUES FOR SIMULTANEOUS DETERMINATION OF INDACATEROL AND GLYCOPYRRONIUM IN INHALATION CAPSULES USED FOR TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Indacaterol and glycopyrronium are co-formulated as a maintenance bronchodilator treatment to relieve symptoms in adult patients with chronic obstructive pulmonary disease (COPD). In the present work; first reported, acc...
HAEMATOLOGICAL CHANGES IN ADMINISTRATION OF AQUEOUS IPOMOEA BATATA LEAF EXTRACT TO WISTAR RATS
Several studies have reported the significance of potato leaf (Ipomoea Batata) on different physiological systems of the human body; most reports have shown it to be medicinal, pharmacological, and efficacious in the tre...
SURVEILLANCE ON COMMUNICABLE DISEASE –INFLUENZA
For better control of communicable diseases, National Communicable Disease Surveillance Systems must be strengthened. Communicable diseases have always been as one of the main threats for human health. Influenza, or flu,...
SURVEY OF THE MAIN VECTORS OF LEISHMANIASIS, FAUNA OF PHLEBOTOMINE SAND FLIES (DIPTERA: PSYCHODIDAE) IN ALBORZ PROVINCE, IRAN
Introduction: Leishmaniasis is a predominantly rural disease with multifaceted clinical manifestations caused by infections with species of Leishmania. Sand flies are the only vectors of the various species of leishmania...