PHYTOCHEMICAL AND PHARMACOLOGICAL INVESTIGATIONS OF RHIZOME EXTRACTS OF KAEMPFERIA GALANGA
Journal Title: International Journal of Pharmacognosy - Year 2014, Vol 1, Issue 3
Abstract
The rhizome of Kaempferia galanga (Family: Zingiberaceae) has been investigated for isolation of secondary metabolites and evaluation of bioactivities. Two cinnamic acid derivatives, Ethyl p-methoxycinnamate (KG-2) and 4-methoxy cinnamic acid (KG-9) have been isolated from the chloroform fraction of the methanolic extract of the rhizome of K. galanga using chromatographic analysis. Structures of these compounds were elucidated by extensive spectroscopic analysis and by comparing the data with the published one. In the carrageenan-induced paw edema test, at a dose of 400 mg/kg the methanolic extract, chloroform and n-hexane fraction showed a significant (p<0.05) inhibition of paw edema with 55.08, 48.85 and 71.88 % inhibition after the 2nd hour of the study period. In acetic- acid-induced writhing test, the chloroform and n-hexane extract at a dose of 400 mg/kg showed a significant (p<0.001) reduction in the number of writhes with38.19 and 62.31 % writhing inhibition respectively. In hypoglycemic evaluation study by oral glucose tolerance test, all of the extracts at 200 mg/kg body weight inhibited the rise in blood glucose level. After 30 minutes of a glucose load, the methanolic extract, and chloroform soluble fraction remarkably reduced blood glucose level with 61.2 and 89.63 % reduction compared to control which were more prominent than that of glibenclamide (34.78% reduction compared to control. The percentage maximal inhibition of glucose load of n-hexane extract vs. control was 133.33 % which was higher than that of the standard. We reported for the first time that the rhizome of K. Galangal showed potential antihyperglycemic activity in mice.
Authors and Affiliations
Zobaer Al Mahmud
Keywords
Related Articles
- EP ID EP427429
- DOI -
- Views 95
- Downloads 0
ANTIMICROBIAL SOCKS FORMULATION WITH SILVER NITRATE
Antiseptics and Disinfectants are extensively used in the health care industry and also equally in personal hygiene. Among the chemicals, silver has long been known to have antimicrobial activity. Development of new, eff...
PHYTOCHEMICAL AND ANTI-CONVULSANT STUDY OF NYCTANTHES ARBOR-TRISTIS EXTRACT
The drug is obtained from the dried fruit of Nyctanthes arbor-tristis of family Oleaceae. It is also called Coral Jasmine, Parijat, and Harsingar etc. To confirm the veracity of aforementioned claim, the anticonvulsant e...
PHARMACOGNOSTICAL PHYTOCHEMICAL SCREENING OF ARISTOLOCHIA BRACTEOLATE (ARISTOLOCHIACEAE)
Aristolochia bracteolate is a small glabrous shrub occurring in India. It belongs to the family Aristolochiaceae. The whole plant is used in various ailments like abortifacient, alterative, anthelmintic, antiperiodic, em...
VARIATION IN PRELIMINARY PHYTOCHEMICALS SCREENING OF CANNABIS SATIVA L. LEAF, STEM AND ROOT
Qualitative phytochemical screening of C. sativa leaf, stem and root was studied. Four solvents viz; n-hexane, chloroform, alcohol and aqueous revealed the variation in phytochemicals presence and absence in all studied...
DETERMINATION OF ANTIOXIDANT ACTIVITY OF CROCUS SATIVUS IN ADJUVANT INDUCED ARTHRITIC MICE
Rheumatoid arthritis (RA) is a chronic systemic disease which results in pain, swelling, and stiffness in joints. It affects about 1% of the total world’s population. RA begins with an edematous thickening of the synovia...