PHYTOCHEMICAL STUDY AND ANTIMICROBIAL ACTIVITIES OF CORDIA DICHOTOMA
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 12
Abstract
The present study was aimed at detecting the phytochemicals and evaluating antimicrobial activities of Cordia dichotoma known for their medicinal properties in folk medicine. Phytochemical screening was carried out on the leaves of Cordia dichotoma; the results latifoliate the presence of alkaloids, proteins, carbohydrates. The assessment of antifungal activity was performed in terms of percentage of radial growth on solid medium (potatoes dextrose agar PDA) against Aspergillus flavus and Penicillium expansum. The antibacterial effect was studied by the agar direct contact method using Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia colistrains. The phytochemical estimation revealed the presence of alkaloids, flavonoids and saponosides. These phytochemicals were isolated from the plant with yields of 5.709 % of Petroleum ether extract, 6.69 % of Chloroform extract, and 9.45 % of methanol extract. Finally, the results of antimicrobial activity of the aqueous extract showed a pronounced antifungal activity against the tested strains. The percentage inhibition values were found to be in the range of 12-24 mm against Candida albicans and 11 to 19 mm against Aspergilus niger. The results revealed that the methanolic extract exhibited significant antimicrobial activity of concentration of 100-500 μ/ml respectively against tested organisms, particularly more effective against Bacilus cereus and Escherichia coli than the other extract when compared to the standard drug (chloramphenicol).
Authors and Affiliations
Suman Rawat , Ruchi Saini , Ankita Sharma
Keywords
Related Articles
- EP ID EP115544
- DOI 10.7897/2230-8407.041212
- Views 101
- Downloads 0
EVALUATION OF ANTIBACTERIAL ACTIVITY OF METHANOLIC EXTRACT OF PLANT RIVEA ORNATA
Phag described in classical text of Ayurveda is botanically identified as Rivea ornata. In present study methanolic extract of plant Rivea ornata was screened for in- vitro antibacterial activity against gram positive an...
ENHANCING SOLUBILITY AND DISSOLUTION OF CELECOXIB BY SPRAY DRYING TECHNIQUE
Celecoxib, a selective COX-2 inhibitor, exhibits poor water solubility, dissolution and flow properties. Thus, the aim of the present study was to improve the solubility and dissolution rate of celecoxib by preparing cry...
EFFECT OF QUERCETIN ON HEPATOPROTECTIVE ACTIVITY OF SILYMARIN AGAINST THIOACETAMIDE INTOXICATED RATS
The study was designed to investigate the interactive effect of Quercetin on hepatoprotective effect of Silymarin against thioacetamide induced hepatotoxicity in rats. Albino rats of either sex were divided into six grou...
A REVIEW ON THE GENUS BAMBUSA AND ONE PARTICULAR SPECIES BAMBUSA VULGARIS IN SABAH (MALAYSIA)
Bamboos are often and widely viewed only on their mechanical and constructions as well as for ornamental and decorative purposes. The curative and medicinal property of bamboos are overlooked or completely ignored and le...
SENSORY AND NUTRITIONAL QUALITY OF SOY FORTIFIED TRADITIONAL PRODUCT
Cereals and pulses are the main constituents of any food all over the world. Cereals are considered as a major source of energy but they content less protein than animal protein. Soybean is one of the pulses that contain...