PHYTOCHEMISTRY AND BIOLOGICAL ACTIVITIES OF CRATEVA ADANSONII EXTRACTS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2018, Vol 10, Issue 9
Abstract
Objective: This study aims to search the secondary metabolites of Crateva adansonii (leaves and bark) and evaluate some biological activities (antimicrobial, antioxidant and cytotoxicity’s property) of these extracts.Methods: The phytochemical screening was made with standard method. Agar diffusion method was used for antibacterial activity coupled with Minimum Inhibitory Concentration (MIC) and Bactericidal (MBC) determination. The antifungal test was performed by the mycelial development reduction method. DPPH method was used to evaluate the extracts antioxidant activity. Artemia salina larvae were use as support to evaluate the toxicity of the extracts.Results: The results of the phytochemical screening reveal the presence of polyphenols, triterpenoids, and glycosides in the both organs (leaves and bark) of C. adansonii. All the extracts have low activity on the reference strains with a larger diameter of 17±00 mm (S. oralis). Only the ethanolic and hydroethanolic leaf’s extracts inhibited respectively 20% and 10%, of the clinical strain S. aureus. The ethyl acetate leaf’s extract shows the best antifungal activity (89,19%) with A. clavatus. All extracts present dose-dependent antiradical properties and are non-toxic for the cells of Artemia salina. C. adansonii bark extracts had the best reducing power (23,80±0, 137 mmol/g EqAA EAA) of the DPPH radical.Conclusion: C. adansonii is therefore an active principle source for the development of drugs to antimicrobial and antioxidant activities
Authors and Affiliations
Martial S. Nounagnon, Durand Dah-nouvlessounon, Christine N’tcha, Boris Legba, Farid Baba-moussa, Adolphe Adjanohoun, Lamine Baba-moussa
Keywords
Related Articles
- EP ID EP566159
- DOI 10.22159/ijpps.2018v10i9.27197
- Views 77
- Downloads 0
EFFECT OF ETHANOLIC EXTRACT OF TERMINALIA ARJUNA ON LIVER FUNCTIONS AND HISTOPATHOLOGY OF LIVER IN ALBINO RATS FED WITH HYPERLIPIDEMIC DIET
Objective: The aim of the present study was to assess the effect of Ethanolic extract of Terminalia Arjuna on Liver functions, Lipid profile and histopathology of liver of albino rats fed with Hyperlipidemic diet.Methods...
PHYTOCHEMICAL ANALYSIS, HEPATOPROTECTIVE AND HPTLC ANALYSIS OF FRACTIONS OF ERYTHROXYLUM MONOGYNUM METHANOLIC LEAF EXTRACT ON PARACETAMOL INDUCED HEPATIC DAMAGE
Objective: To investigate the hepatoprotective activity of fractions of E. monogynum methanolic leaf extract against paracetamol induced hepatic damage and perform HPTLC analysis of active fraction.Methods: Fractions der...
FLAVONOIDS FROM SUGAR BEET LEAVES AS HEPATOPROTECTIVE AGENT
Objective: This work was designed to investigate the activity of Beta vulgaris (B. vulgaris) extract against hepatotoxicity induced by (carbon tetrachloride) CC14 in male rats.Methods: Hepatoprotective study was performe...
ANTI-INFLAMMATORY ACTIVITIES OF FRUIT AND LEAVES EXTRACT OF LANNEA MICROCARPA ENGLAND K. KRAUS (ANACARDIACEAE)
Objective:Â To investigate the anti-inflammatory activity as well as carotenoid content of crude hydro-acetonic extract of fruit and leaves of Lannea microcarpa (L. microcarpa) and to elucidate the possible anti-inflamm...
DRUG UTILISATION REVIEW IN POSTOPERATIVEPATIENTS IN OBSTETRICS-GYNAECOLOGY AND SURGICAL GASTROENTEROLOGY DEPARTMENTS-A RETROSPECTVE STUDY
Objective: The main objectives of our study include classification, analysis and assessment of all the post-operative drugs present of our study.Methods: The current project being a retrospective drug utilization review...