Plasma biomarkers of endothelial dysfunction in patients with hypertrophic cardiomyopathy.
Journal Title: Pharmacological Reports - Year 2007, Vol 59, Issue 6
Abstract
Impairment of endothelium-dependent coronary vasodilatation has been reported in hypertrophic cardiomyopathy (HCM). The aim of our study was to evaluate whether HCM patients have increased circulating blood markers of endothelial dysfunction. We compared 29 HCM patients with sinus rhythm, including 11 with the left ventricular outflow tract (LVOT) obstruction (gradient > 30 mmHg), versus 29 age- and sex-matched controls without cardiovascular diseases. Plasma levels of the following endothelial biomarkers were determined: soluble thrombomodulin (sTM), von Willebrand factor (vWF), tissue factor pathway inhibitor (TFPI), asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDAM) and L-arginine to ADMA (Arg/ADMA) ratio. Both sTM (49.1 +/- 9.9 vs. 39.1 +/- 4.8 ng/ml, p < 0.00001) and TFPI (18.6 +/- 2.5 vs. 16.2 +/- 1.7 ng/ml, p < 0.0001) were elevated in HCM patients compared with controls, whereas vWF levels were similar in both groups (105.8 +/- 11.6 vs. 102.2 +/- 10.9 U/dl, p > 0.05). Among markers related to the nitric oxide pathways, we observed elevations of both ADMA (0.57 +/- 0.08 vs. 0.44 +/- 0.04 mumol/l, p < 0.0001) and SDMA(0.43 +/- 0.05 vs. 0.34 +/- 0.04 mumol/l, p < 0.0001) and decrease in the Arg/ADMAratio (118.1 +/- 18.2 vs. 144.3 +/- 22.1, p < 0.0001) in HCMpatients. The obstructive HCMsubgroup displayed higher values of ADMA, SDMAand sTM compared with the non-obstructive HCM subgroup. HCM patients show specific features of endothelial dysfunction detectable in peripheral blood, involving increased sTM and TFPI, but not vWF, along with increased ADMA levels.
Authors and Affiliations
Paweł P Dimitrow, Anetta Undas, Maria Bober, Wiesława Tracz, Jacek Dubiel
Keywords
Related Articles
- EP ID EP96661
- DOI -
- Views 92
- Downloads 0
Biotechnology and genetic engineering in the new drug development. Part I. DNA technology and recombinant proteins.
Pharmaceutical biotechnology has a long tradition and is rooted in the last century, first exemplified by penicillin and streptomycin as low molecular weight biosynthetic compounds. Today, pharmaceutical biotechnology st...
Epicutaneous immunization with myelin basic protein protects from the experimental autoimmune encephalomyelitis.
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system (CNS) with limited treatment modalities. One of the experimental methods that protect from autoimmune diseases is oral to...
Enhanced anti-ulcer effect of pioglitazone on gastric ulcers in cirrhotic rats: The role of nitric oxide and IL-1β.
Background: The frequency of gastrointestinal ulcerations is higher in cirrhotic patients than in the normal population. It has been shown that pioglitazone exhibits gastroprotective actions. This study was designed to i...
Neuroprotective effect of carvedilol against aluminium induced toxicity: possible behavioral and biochemical alterations in rats.
Aluminium, is a trace element available in the Earth's crust naturally and has a toxic potential for humans. It has been suggested as a contributing factor in the pathogenesis of Alzheimer's disease. β-Adrenoceptor block...
Impact of endocrine-disrupting chemicals on neural development and the onset of neurological disorders.
Even though high doses of organic pollutants are toxic, relatively low concentrations have been reported to cause long-term alterations in functioning of individual organisms, populations and even next generations. Among...