Plasma Homocysteine, Folate and B12 Vitamin Levels in Alzheimer Disease, Vascular Dementia and Mild Cognitive Impairment
Journal Title: Journal of Neurological Sciences-Turkish - Year 2006, Vol 23, Issue 3
Abstract
Purpose: Elevated plasma total homocysteine(Hcy) concentrations are associated with Alzheimer’s disease(AD) and vascular dementia(VaD). The purpose of this study is to examine the association of dementia with blood levels of Hcy, and its biological determinants folate and vitamin B12. Methods: The studied groups of 28 cerebro vascular disease(CVD) patients, 22 VaD patients, 51 AD patients, 20 mild cognitive impairment (MCI) and 25 healthy elderly subjects. These patients and control subjects were studied for Hcy, vitamin B12, and folate. Results: All patients and control subjects were compared for age, sex, educational level, and Hcy, folate and Vit.B12 levels. Hcy was significantly increased in VaD patients (mean ±.SD= 17.8±5.5 µmol/L) and AD patients (mean ±.SD=14.2±3.1 µmol/L. p
Authors and Affiliations
Yahya KARAMAN
Keywords
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