POPULATION PHARMACOKINETICS OF CONTINUOUS INFUSION OF FACTOR VIII IN HEMOPHILIA-A PATIENTS UNDERGOING ORTHOPEDIC SURGERY
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 2
Abstract
Objective: to develop a population pharmacokinetic model taking into account blood losses during and after orthopedic surgery in adult hemophilia A patients receiving infusion of coagulation factor VIII, and to evaluate the influence of potential covariates.Methods: Factor VIII pharmacokinetic parameters were calculated from 24 patients. Among them, 7 were HIV+. The observations were analyzed with the mixed-effects compartment pharmacokinetic package NONMEM and the first-order conditional estimation method. To evaluate the stability and robustness of the final model the bootstrap method was used.Results: During the model-building process, central volume of distribution (V1) was related to body weight (P = 0.0263) and viral status (P = 0.0078). Moreover, the peripheral volume of distribution was related to body weight (P=0.0362). In the final model, only the viral status was significant for V1 when compared with the base model. Posterior predictive checks and robustness analysis showed that the model adequately described the pharmacokinetic parameters. The HIV covariate accounted for 29.8% of the unexplained variation across patients for V1. V1 increased by 33.3% in HIV+ patients compared to HIV- patients.Conclusion: A population pharmacokinetic model taking into account blood losses during and after orthopedic surgery was developed. The 33.3% increase in V1 observed in HIV+ patients explained the need for higher doses in these patients.Â
Authors and Affiliations
Magali Bolon-larger, FranÇoise Bressolle, Yoann Chevalier, Valerie Chamouard, Roberto Gomeni, Roselyne Boulieu
PROTECTIVE AND ANTIDIABETIC EFFECTS OF VIRGIN COCONUT OIL (VCO) ON BLOOD GLUCOSE CONCENTRATIONS IN ALLOXAN INDUCED DIABETIC RATS
Objective: The present study was carried out to evaluate if Virgin Coconut Oil (VCO) exerts any protective or regenerative effects on pancreatic β cells in Alloxan induced diabetic rats and to observe and determine the...
THE WONDERS OF A MEDICINAL TREE: HOLOPTELEA INTEGRIFOLIA (ROXB.) PLANCH
In this busy era of herbal sciences, extensive study is being carried out on numerous plants to find novel drugs among which Holoptelea integrifolia Roxb. (Indian Elm) tree is just one of them. The age old knowledge ethn...
DEVELOPMENT OF VALIDATED STABILITY INDICATING METHOD BY RP-HPLC FOR SIMULTANEOUS ESTIMATION OF MEROPENEM AND VABORBACTAM IN BULK AND PHARMACEUTICAL FORMULATION
Objective: To develop a simple, rapid, precise and reproducible liquid chromatographic method for the estimation meropenem (MEP) and vaborbactam (VAB) in bulk and pharmaceutical formulation and study of the stability of...
EVALUATION OF THE ANTICONVULSANT EFFECT OF AQUEOUS EXTRACT OF CENTELLA ASIATICA IN ALBINO MICE
Objective: To evaluate the antiepileptic activity of aqueous extract of Centella asciatica in maximal electroshock (MES) and pentylenetetrazole (PTZ) induced convulsions. Methods: The anticonvulsant activity of leaves of...
DEVELOPMENT AND VALIDATION OF PATIENT INFORMATION LEAFLET FOR HEART ATTACK PATIENTS
Objective: To prepare a validated heart attack patient information leaflet and to educate and promote the patient knowledge regarding the disease, lifestyle modification, and medication.Methods: The patient information l...