Abstract

The integumentary system is soft a highly organized structure of epidermis and dermis, which is tightly conjugated with each other. The epidermis represents the outer covering and is formed of epidermal layers, Langerhan, Merkel cell, melanocytes and immune cells travestied by hair follicles. Sweat glands are infiltrated throughout the integumentary layers, including fibroblast, and mast cells. Hair follicles with complex structure, characterized with their complicated structures and their internal structure contains immune cells during differentiation and possesses sebaceous glands for sebum productionthe antibacterial components. A calcium and potassium ion in close association with lipid and cholesterol represents the main elements in epidermal permeability. Keratinocytes represent the elementary part for cholesterol and lipid formation. Cholesterol overload led to altered cell structure, hair follicle formation, integrity of blood vessels and dermal collagen. It caused deformation of hair follicles and disrupted epidermal structures and keratinocyte formation leading to impairing keratinization. Fish oil represents one of the main food additives having biomedical importance. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) represent their main components and play a great role in promoting permeability, growth and differentiation of the stratum corneum and inhibition of proinflammatory cytokines (tumor necrosis factor-α, interferon-γ, and interleukin-12 which improve the diabetic and hypercholesterolemic complications.

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