POTENTIAL ANTIMICROBIAL, ANTHELMINTIC AND ANTIOXIDANT ACTIVITIES OF MYRISTICA DACTYLOIDES GAETRN BARK
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 5
Abstract
Objective: The present study was undertaken to determine the antimicrobial, anthelmintic and antioxidant activities of bark extracts of Myristica dactyloides Gaetrn.Methods: The antimicrobial activity of the petroleum ether, ethyl acetate and methanol extracts were evaluated by the Agar well diffusion method against different gram-positive, gram-negative bacteria and fungi. Different extracts of the plant were taken for anthelmintic activity against Indian earthworm Pheretima Posthuma. DPPH radical scavenging activity was measured by the DPPH antioxidant assay method using ascorbic acid as standard and the total phenolic content was estimated spectrophotometrically using Folin-Ciocalteu method.Results: Petroleum ether extract exhibited significant antifungal activity, anthelmintic activity and considerable DPPH radical scavenging activity with an IC50 value of 10.97±0.07µg/ml. Whereas methanol extract exhibited significant antibacterial activity against both gram positive and gram negative bacteria and it is the richest source of phenolics with a total phenolic content of 95.11±2.14 mg of Catechol equivalents/100 mg dried extract. Preliminary phytochemical screening revealed the presence of alkaloids, flavonoids, tannins/phenolics, steroids/triterpenoids and saponins which may be the reason for its biological properties.Conclusion: The findings of this study indicate that this plant is medicinal with prominent antioxidant, antimicrobial and anthelmintic property. The plant can be considered as promising plant species with high potential value for drug preparation.Â
Authors and Affiliations
Ajish A. D. , Vagdevi H. M. , Asha K, Jayanna N. D.
Keywords
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