Potential Autoepitope within the Extracellular Region of Contactin-Associated Protein-like 2 in Mice
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2014, Vol 4, Issue 1
Abstract
Aims: Implicated in autoimmune encephalitis, neuromyotonia and genetic forms of autism, here we report that contactin-associated protein-like 2 (CNTNAP2) contains a potential autoepitope within the extracellular region. Methodology: CNTNAP2 sequence-similar regions (CSSRs) from human pathogens were identified. Sera from autistic and control children were obtained and analyzed for the presence of antibodies able to bind CSSRs. One such candidate CSSR was evaluated for evidence of autoimmune responses to CNTNAP2 in a mouse model of acute infection. Results: Autistic and control children sera contained antibodies able to discrete regions of CNTNAP2. In a murine model of acute infection, a CSSR derived from the N-terminal extracellular region of CNTNAP2 resulted in anti-CNTNAP2 antibody production, proinflammatory cytokine elevation, cerebellar and cortical white matter T-cell infiltration as well as motor dysfunction. Conclusion: Taken together, these data suggest that CNTNAP2 contains a potential autoepitope within the extracellular region.
Authors and Affiliations
Demian F. Obregon, Yuyan Zhu, Antoinette R. Bailey, Samantha M. Portis, Huayan Hou, Jin Zeng, Saundra L. Stock, Tanya K. Murphy, Michael A. Bengtson, Jun Tan
Keywords
Related Articles
- EP ID EP348642
- DOI 10.9734/BJMMR/2014/6135
- Views 75
- Downloads 0
Clinical and Imaging Findings of Symptomatic Right Aortic Arch and Double Aortic Arch: Case Report
Aim: Anomalies of aortic arch are uncommon, accounting for only 1-3% of all congenital cardiac diseases. A vascular ring results from the abnormal development of an aortic arch complex. Generally, it manifests with trach...
Internal Medicine as a Career Choice among Rotatory Interns in a Developing Country- A Multi Centre Study
There is shortage of medical manpower including internists in Nigeria. Young interns prefer certain specialties to the neglect of others. This creates a gap in health care delivery. Objectives: The aim of the study was t...
Association of Major Depression with Serum Prolidase Activity and Oxidative Stress
Aim: Stress is a major causative factor for the progression of major depressive disorder (MDD). The present study aimed to know the association of serum prolidase activity (SPA) and oxidative stress with the progression...
Prediction of Intrauterine Growth Restriction in High Pulsatility Index of Uterine Artery
Introduction: Intrauterine growth restriction is a significant cause of neonatal mortality. The uterine artery Doppler waveform becomes transformed into a high flow with low resistance at 22-24 weeks. The apt way to redu...
P53 and Ki67 Expression by Cervical Cancers in Ile-Ife, Nigeria
Background: Cervical cancer is the second most common cause of cancer deaths in females in Nigeria. The aim of this study is to determine the percentage of cervical cancers in Ile-Ife that express the p53 and Ki-67 prote...