Potential Deleterious Effects Following the First Dose of Medroxyprogesterone Acetate as a Contraceptive in Cats
Journal Title: Journal of Applied Veterinary Sciences - Year 2023, Vol 8, Issue 4
Abstract
The aim of the present work was to investigate the deleterious effects of the first dose of medroxyprogesterone acetate (MPA) on the female genital system of cats. The study was conducted on 315 cats of different breeds who received their first dose (75 mg) of MPA as a contraceptive. Complete animal identification and stage of estrus were documented at admission. Physical, radiographic and ultrasonographic examinations were done on cats that expressed deleterious manifestations. All of the presented cats received an overdose of MPA during the estrous phase of the estrous cycle. Out of 315 cats who received their first dose of MPA, 27 (8.6 %) demonstrated varied deleterious effects related to the female genital system. Deleterious effects were reported within 15â90 days, including pyometra (n=10, 37.0%), endometritis (n=8, 29.6%), mammary gland hyperplasia (n=4, 14.8 %), cystic endometrial hyperplasia (n=3, 11.2%) and ovarian cyst (n=2, 7.4%). The incidence of these adverse effects increased with age. Persian cats seem to be more susceptible than other cat breeds. Long haired cat breeds seem to be more susceptible to adverse effects following injection of exogenous progestins (MPA) than short haired breeds (Siamese and Egyptian mau). Deleterious effects of MPA occurred following the first overdose. It is advised to use MPA as a contraceptive in the recommended dose during the inter-estrous or anestrous phase.
Authors and Affiliations
Ahmed Abdelgalil,
Keywords
Related Articles
- EP ID EP721435
- DOI -
- Views 33
- Downloads 0
Struvıte Bladder Stone in A Cat Wıth Hyperthyroıdısm: Case study
Urinary crystals and uroliths could harm cats by causing local or systemic symptoms that could vary from mild to severe. Regardless of the type of stone, the diagnostic methods are the same. However, in addition to dete...
Histopathological Study of Orlistat and Rosemary Aqueous Extract in the Brain and Liver of Obese Male Rats
This study aimed to see how induced obesity, orlistat, and aqueous rosemary extract, affected albino rats' brains and livers. The rats were divided into 7 different groups. Each group contains 6 rats. The first group was...
A Typical Case of Chronic Myeloid Leukemia (CML) in A Native Shepherd Dog in Duhok Province, Iraq
A typical case of a 7-years-old Kurdish male shepherd dog was referred with two weeks history of lethargy, restlessness, anorexia and severe emaciation. Physical examination of the dog revealed generalized lymphadenopath...
Pharmacodynamic and Pharmacokinetic Comparison between Selective and Non-selective COX-2 Inhibitors in Mice
Nowadays, there is a need for good and efficacious NSAIDs with minimal side effects to be applied in veterinary medicine. The aim was to compare the pharmacodynamics (analgesia and inhibition of COX-2) and pharmacokineti...
Isolation and Identification of Salmonella from Chickens Prepared for Slaughter in the State of Kuwait
Salmonella enterica serovar Enteritidis throughout the world, is frequently linked to food-borne illness. Products made from poultry are important sources of transmission. Therefore, this study aimed to identify the inci...