POTENTIAL ROLE OF GROWTH AND DEFFERENTIATION FACTORS IN PERIODONTAL REGENERATION
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2018, Vol 7, Issue 10
Abstract
Growth factors are polypeptide hormones or biological factors. They mediate many cellular processes necessary for the various stages of growth, induction of phenotypic expression, and even the metamorphosis of totipotent germ cells into pluripotent stem cells.[1,2] A totipotent germ cell is a single cell that can recapitulate or repeat development, demonstrating the capacity to develop and differentiate into a complete organism.[2,3] A pluripotent stem cell is “capable of differentiating into several different final differentiated types.”[3] When germ cells are cultured in certain polypeptide growth factors, they can be stimulated to transform into pluripotent stem cells. 2 Growth factors are also known to influence the growth rate of certain cancers.[4] Many tissues are mediated by growth factors: epithelium and endothelium; myocardium and neural tissue; cartilage, bone, and cementum; the more specialized types of connective tissue and blood: and the less specialized connective tissue replete with extracellular matrix, such as collagen and proteoglycans that surround other more highly developed tissues and organs.[1] Polypeptide growth and differentiation factors (GDFs) are classified as biological mediators that have demonstrated a significant role in stimulating and regulating the wound healing process. The growth factors associated with repair and regeneration coordinate important cellular processes such as:[1]
Authors and Affiliations
Ali Kadhim Jalil
Keywords
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